Prestwick C. elegans Library
The first C. elegans library of drugs designed for Caenorhabditis elegans research programs
A collection of 240 small molecules that have been carefully selected for chemical structural diversity as well as for good tolerability in C. elegans.
Why a C. elegans library?
C. elegans models of human disease hold great promise for the discovery of new treatments. Screening of drugs on these models, however, is complicated by drug toxicities specific to C. elegans as well as by poor tolerance of C. elegans for most organic solvents (used to dissolve drugs).
Therefore, the selection of drugs was made by using several criteria such as: known safety and bioavailability in humans, chemical diversity, therapeutic diversity, solubility or toxicity for C. elegans.
What makes the C. elegans chemical screening library uniquely useful is that its compounds are marketed drugs selected for their known bioavailability and safety in humans.
The C. elegans library is packaged as 10 mg dry powder in vials. All compounds have purity higher than 90%.
A database ready for use:
Provided with a well annotated database as structural data file (SDF), IsisBase (DB) as well as an XLS file. Annotation includes target, therapeutic class/effect, side effects, solubility and the highest tolerated (non deleterious) concentration in C.elegans.
The Library is sold with "no strings attached" (i.e. no royalties or milestones are requested).