PRESTWICK DRUG FRAGMENT LIBRARY



Prestwick Drug-Fragment Library

Unique collection of fragments

Acknowledged as powerful tool for successful identification of lead series, fragment-based drug design is widely implemented in industry and academia. To meet researchers expectations, Prestwick Chemical medicinal chemists designed a unique collection of 1464 small molecules (MW<300) arising from the smart fragmentation of 1500 approved drugs (up to year 2016).

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PRESTWICK CHEMICALKeys and Benefits:

    PRESTWICK CHEMICAL Good coverage of lead-like diversity space
    PRESTWICK CHEMICAL High-quality hit increased by using fragments derived from approved drugs
    PRESTWICK CHEMICAL Rapid follow-up on primary hits possible
    PRESTWICK CHEMICAL Experimental solubility in DMSO (100 mM) and PBS (1 mM) available
    PRESTWICK CHEMICAL Purity 95%+ (H NMR spectrum and LC/MS available)
    PRESTWICK CHEMICAL Balanced set of Ro3 compliant (55%) and non compliant Ro3 (45%) fragments
    PRESTWICK CHEMICAL 818 molecules (56%) are exclusive to the Prestwick Drug-Fragment Library and cannot be found in any other major supplier of fragment libraries


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PRESTWICK CHEMICALAvailable Formats:



Format



Comments



Core set
480 cpds

PRESTWICK CHEMICAL DMSO solution (up to 100 mM)
PRESTWICK CHEMICAL Ready for screening
Representative set of the entire library
Highly recommanded for rapid outcomes

Entire library
1464 cpds

PRESTWICK CHEMICAL Undissolved (>10 mg)
PRESTWICK CHEMICAL DMSO solution (up to 100 mM)
Available for cherry picking

Customized
set

PRESTWICK CHEMICAL Undissolved (>10 mg)
PRESTWICK CHEMICAL DMSO solution (up to 100 mM)
Selection based on your own criteria
(physchem properties, substructure or similary search)

Re-supply guaranteed



PRESTWICK CHEMICALApplication:

    PRESTWICK CHEMICAL Fragment screening (X-ray crystallography, NMR, SPR, high concentration bioassay, …)
    PRESTWICK CHEMICAL HTS for small molecules


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The Prestwick Drug-fragment Library:
an innovative tool for FBDD

    It is commonly recognized that the quality of screening libraries has a crucial impact on the hit rate and on the pertinence of the obtained hits. In order to guarantee to customers a high level of performance, Prestwick Chemical has developed a range of valuable libraries designed for specific applications.
    A library of 1464 fragments, the Prestwick Drug-Fragment Library, was built from the careful and smart fragmentation of 1500 approved drugs (up to year 2016).1-2 The generation, properties and advantages of this new library, dedicated to fragment based drug discovery (FBDD), will be presented and discussed in the present poster.

Prestwick fragments match 85% of 2017 FDA-approved drugs

    PRESTWICK CHEMICAL A unique set of 1464 fragments designed by manual smart fragmentation from approved drugs (FDA, EMA...) up to year 2016
    PRESTWICK CHEMICAL Two subsets: Ro3 compliant (808 fragments) and Beyond Ro3 (656 fragments)
    PRESTWICK CHEMICAL Expansion from drug fragment-hits allows the synthesis of molecules with appropriate ADMET properties

Posters / Flyer
Drug-Fragment Library

at International Meetings

This chemical screening library is sold with "no strings attached"