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Case studies
Drug Repositioning as a Therapeutic Strategy against Streptococcus pneumoniae: Cell Membrane as Potential Target

Laura Ortiz-Miravalles, Manuel Sánchez-Angulo, Jesús M Sanz , Beatriz Maestro
Int. J. Mol. Sci. 5831 (2023)

A collection of repurposing drugs (Prestwick Chemical Library) containing 1200 compounds was screened to investigate the drugs’ antimicrobial effects against planktonic cultures of the respiratory pathogen Streptococcus pneumoniae. After four discrimination rounds, a set of seven compounds was finally selected, namely (i) clofilium tosylate; (ii) vanoxerine; (iii) mitoxantrone dihydrochloride; (iv) amiodarone hydrochloride; (v) tamoxifen citrate; […]

Case studies
Use of the Prestwick Chemical Drug-Library for COVID research

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication.

F. Touret, M. Gilles, K. Barral, A. Nougairède, E. Decroly, X. de Lamballerie & B. Coutard
bioRxiv (2020)

Repurposing of approved drugs is a strategy that can bypass the time-consuming stages of drug development. In this study, the researchers screened the PRESTWICK CHEMICAL LIBRARY composed of 1,520 approved drugs in an infected cell-based assay. The robustness of the screen was assessed by the identification of drugs that already demonstrated in vitro antiviral effect […]

Case studies
Drug repurposing: a compound from the Prestwick Chemical Library Riboflavin Completed Phase 2 Trials for Stroke, Ischemic Treatment

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke.

A. da Silva-Candal, A. Pérez-Diaz, M. Santamaria, C. Correa-Paz, M. Rodriguez-Yanez, A. Arda, M. Perez-Mato, R. Iglesias-Rey, J. Brea, J. Azuaje, E. Sotelo, T. Sobrino, MI Loza, J. Castillo & F. Campos.
Ann. Neurol. 84 260–273 (2018)

Blood/brain-glutamate grabbing is an emerging concept in the treatment of ischemic stroke, where essentially the deleterious effects of glutamate after ischemia are ameliorated by coaxing glutamate to enter the bloodstream and thus reducing its concentration in the brain. The authors aim to demonstrate the clinical efficacy of blood glutamate grabbers in patients with stroke, and […]