Prestwick Original Molecules Library

Prestwick Original Molecules Library : innovative and exclusive screening compounds

An original collection of 344 exclusive compounds: Your Premium Resource For Novel Screening Hits.
All molecules have been designed to ensure optimal diversity and are suitable for diverse chemical modification yielding analogs with promising IP positions. The library combines favorable drug-like and ADME-Tox properties with high potential therapeutic score.

Prestwick Original Molecules Library : key features

  • An original collection of 344 exclusive compounds
  • Designed considering drug-like properties
  • Optimal diversity, suitable for multiple chemical modifications
  • Promising IP positions – Mean MW: 395
  • Innovative compounds with favorable lead-like (Oprea) and drug-like (Lipinski) properties

  • Using a structure-based approach (pharmacophore-based virtual screening), each compound was investigated for its potential interactions with protein targets ranging from CNS to oncology, cardiovascular and antimicrobial fields. Target prediction allows to claim that the selected Prestwick Original Molecules (POM) might be active in different therapeutic areas.

Prestwick Original Molecules Library : how provided?

  • In DMSO at 10 mM (from 100 µL up to 1 mL) ready for screening in 96 or 384 well plates. Customized library (volumes, plating) achieved under request
  • As dry powder in vials starting from 10 mg, with cherry-picking possibility
  • The database is supplied in three formats (SDF, DB, XLS)
  • Re-supply of any hit-compound up to 100 mg

Prestwick Original Molecules Library : applications

  • Small molecule screening
  • Original starting point in hit/lead discovery programs


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