Publications

Publications
The oxidative and carbonyl stress axis in anti-vascular endothelial growth factor-refractory neovascular age-related macular degeneration: Implications for therapeutic repurposing

 Castro-Fernández DC, Cañizo-Outeiriño A, Martínez AL, Cuartero-Martinez A, Rodríguez-Martínez L, González-Barcia M, Fernández-Rodríguez MI, Rodríguez-Cid MJ, Abraldes MJ, Almuiña-Varela P, Mera-Yáñez MP, de Domingo B, Gil-Martínez M, Méndez-Cepeda MDP, Pazos-González B, Goméz-Ulla F, Loza MI, Ortea I, Brea J, Mateos J, Fernández-Ferreiro A
 European Journal of Medicinal Chemistry 320 119361 (2026)

Background and purpose Neovascular age-related macular degeneration is a leading cause of irreversible blindness, and approximately 25% of patients respond inadequately to intravitreal anti-VEGF therapy, representing a major unmet clinical need. We aimed to identify repurposable therapeutic alternatives by anchoring a phenotypic screen in the molecular signature of inadequate responders. Experimental approach The molecular phenotype […]

Publications
Development of a Cost-Effective and Low-Toxicity Safranin-Based Assay for Discovering Candida Albicans Biofilm Formation Inhibitors in Large-Scale Screening Campaigns

 Vazquez-Rodriguez, A.; Lopez-Ribot, J. L.
 J Fungi (2026)

Screening assays for discovering Candida albicans biofilm inhibitors typically measure either metabolic activity or attached biomass. Although biomass staining with Crystal Violet or Safranin is affordable and easy to perform, standard protocols often require toxic solvents for biofilm fixation and dye extraction. We developed and evaluated an alternative Safranin staining method that uses heat fixation […]

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