Publications PAX8 Modulates the Tumor Microenvironment of High Grade Serous Ovarian Cancer through Changes in the Secretome
Salvi, A.; Hardy, L. R.; Heath, K. N.; Watry, S.; Pergande, M. R.; Cologna, S. M.; Burdette, J. E.
Neoplasia 36, 100866 (2023)
High grade serous ovarian cancer (HGSC) arises from the fimbriated end of the fallopian tube epithelium (FTE), and in some cases, the ovarian surface epithelium (OSE). PAX8 is a commonly used biomarker for HGSC and is expressed in ∼90% of HGSC. Although the OSE does not express PAX8, murine models of HGSC derived from the […]
Publications Novel Non-Stimulants Rescue Hyperactive Phenotype in an Adgrl3.1 Mutant Zebrafish Model of ADHD
Sveinsdóttir, H. S.; Christensen, C.; Þorsteinsson, H.; Lavalou, P.; Parker, M. O.; Shkumatava, A.; Norton, W. H. J.; Andriambeloson, E.; Wagner, S.; Karlsson, K. Æ
ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia, and hypertension. Therefore, the development of non-stimulant-based therapeutics has been prioritized. However, many of these also cause other effects, most notably somnolence. Here, we have used a uniquely powerful genetic model and unbiased […]
Publications Drug Screening Approach against Mycobacterial Fatty Acyl-AMP Ligase FAAL32 Renews the Interest of the Salicylanilide Pharmacophore in the Fight against Tuberculosis
Le, N.-H.; Constant, P.; Tranier, S.; Nahoum, V.; Guillet, V.; Maveyraud, L.; Daffé, M.; Mourey, L.; Verhaeghe, P.; Marrakchi, H.
Bioorg Med Chem 71, 116938 (2022)
Tuberculosis (TB) remains a global health crisis, further exacerbated by the slow pace of new treatment options, and the emergence of extreme and total drug resistance to existing drugs. The challenge to developing new antibacterial compounds with activity against Mycobacterium tuberculosis (Mtb), the causative agent of TB, is in part due to unique features of […]
Publications A New Use for Old Drugs: Identifying Compounds with an Anti-Obesity Effect Using a High through-Put Semi-Automated Caenorhabditis Elegans Screening Platform
Haerkens, F.; Kikken, C.; Kirkels, L.; van Amstel, M.; Wouters, W.; van Doornmalen, E.; Francke, C.; Hughes, S.
Heliyon 8 (8), e10108 (2022)
Obesity is one of the most common global health problems for all age groups with obese people at risk of a variety of associated health complications. Consequently, there is a need to develop new therapies that lower body fat without the side effects. However, obesity is a complex and systemic disease, so that in vitro […]
Publications A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity
Cortés-Kaplan, S.; Kurdieh, R.; Hasim, M. S.; Kaczmarek, S.; Taha, Z.; Maznyi, G.; McComb, S.; Lee, S.-H.; Diallo, J.-S.; Ardolino, M.
Cancers (Basel) 14 (12), 2832 (2022)
Due to their crucial role in tumor immunity, NK cells have quickly became a prime target for immunotherapies, with the adoptive transfer of NK cells and the use of NK cell engagers quickly moving to the clinical stage. On the other hand, only a few studies have focused on small molecule drugs capable of unleashing […]
Publications A New Topical Candidate in Acne Treatment: Characterization of the Meclozine Hydrochloride as an Anti-Inflammatory Compound from In Vitro to a Preliminary Clinical Study
Grange, P. A.; Ollagnier, G.; Beauvais Remigereau, L.; Nicco, C.; Mayslich, C.; Marcelin, A.-G.; Calvez, V.; Dupin, N.
Biomedicines 10 (5), 931 (2022)
Acne is a chronic inflammatory multifactorial disease involving the anaerobic bacterium Cutibacterium acnes (C. acnes). Current acne treatments are associated with adverse effects, limiting treatment compliance and use. We showed that meclozine, an anti-histaminic H1 compound, has anti-inflammatory properties. In Vitro, meclozine reduced the production of CXCL8/IL-8 and IL-1β mRNA and protein by C. acnes-stimulated […]
Publications Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity
Magdy, T.; Jouni, M.; Kuo, H.-H.; Weddle, C. J.; Lyra-Leite, D.; Fonoudi, H.; Romero-Tejeda, M.; Gharib, M.; Javed, H.; Fajardo, G.; Ross, C. J. D.; Carleton, B. C.; Bernstein, D.; Burridge, P. W.
Circulation 145 (4), 279–294 (2022)
BACKGROUND: Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and the intronic variant rs885004 in SLC28A3 (solute carrier family 28 member 3) as statistically associated with a lower incidence of anthracycline-induced cardiotoxicity. However, the true causal variant(s), the cardioprotective mechanism of this locus, the role of SLC28A3 and other […]
Publications High-Throughput Cell-Based Assays for Identifying Antagonists of Multiple Smoking-Associated Human Nicotinic Acetylcholine Receptor Subtypes
Kassner, M.; Eaton, J. B.; Tang, N.; Petit, J. L.; Meurice, N.; Yin, H. H.; Whiteaker, P.
SLAS Discovery 27 (1), 68–76 (2022)
There is substantial evidence that in addition to nicotine, other compounds found in tobacco smoke significantly influence smoking behavior. Further, recent years have seen an explosion in the availability of non-combusted products that deliver nicotine, such as e-cigarettes and “home-brew” vaping devices that are essentially unregulated. There are many thousands of compounds in tobacco smoke […]
Publications A High-Throughput Chemical Screen in DJ-1β Mutant Flies Identifies Zaprinast as a Potential Parkinson’s Disease Treatment
Sanz, F. J.; Solana-Manrique, C.; Torres, J.; Masiá, E.; Vicent, M. J.; Paricio, N.
Neurotherapeutics 18 (4), 2565–2578 (2021)
Dopamine replacement represents the standard therapy for Parkinson’s disease (PD), a common, chronic, and incurable neurological disorder; however, this approach only treats the symptoms of this devastating disease. In the search for novel disease-modifying therapies that target other relevant molecular and cellular mechanisms, Drosophila has emerged as a valuable tool to study neurodegenerative diseases due […]
Publications Sanguinarine Inhibits the 2-Ketogluconate Pathway of Glucose Utilization in Pseudomonas Aeruginosa
Falchi, F. A.; Borlotti, G.; Ferretti, F.; Pellegrino, G.; Raneri, M.; Schiavoni, M.; Caselli, A.; Briani, F.
Front Microbiol 12, 744458 (2021)
Interfering with the ability of pathogenic bacteria to import glucose may represent a new promising antibacterial strategy, especially for the treatment of infections occurring in diabetic and other hyperglycemic patients. Such patients are particularly susceptible to infections caused by a variety of bacteria, among which opportunistic pathogens like Pseudomonas aeruginosa. In P. aeruginosa, glucose can […]