Prestwick CNS-penetrant Drug Library

Prestwick CNS-penetrant Drug Library:
A Unique Library of 320 CNS drugs

The complexity of CNS diseases, the challenge of central drug delivery in combination with the high attrition rate of therapeutic candidates during development make CNS drug approval more difficult compared to other therapeutic areas. To help you identify high-quality hits, 320 structurally diverse approved drugs were carefully selected by a pharmacist-chemist team for their known pharmacological effects on the Central Nervous System.

This Library will be a useful tool for the discovery of compounds dedicated to the treatment of brain diseases, such as brain tumors, mental disorders, and neurodegenerative diseases.


CNS-penetrant Drug Library: A unique and diversified library of approved CNS-drugs

  • Structurally diverse, medicinally active, CNS-penetrant and cell permeable compounds
  • Certified pharmacological effect on the central nervous system
  • High degree of diversity in terms of biological targets (see below)
  • Large panel of therapeutic uses
  • High-quality hits guaranteed, suitable for chemical optimization
  • Small molecule drugs (mean MW: 290)
  • Constant in-house quality control ensuring high purity and stable compounds


Request an XLS or SD file!


CNS Drug Library: Multi-format suitable for different research modalities

  • In powder form, 10-100mg with cherry-picking options
  • Pre-dissolved at 10mM in DMSO, ready for screening (any volume from 100µL to 1mL)
  • In 96 or 384 well plates (Greiner/ Micronics) or in customers’ plates
  • Optional 2D barcodes offer
  • Customization for volume or mapping
  • Stability in DMSO: 5 years at -20°C
  • Shipping under dry ice conditions
  • Always provided with a highly annotated database as structural data file (SDF), IsisBase (DB) as well as an XLS file
  • Database annotation includes target, therapeutic class/effect, side effects, patent, ADMET information, BBB crossing, …
  • Re-supply of any hit-compound up to 100 mg

CNS Drug Library: Multiple applications mostly dedicated to neuroscience research

  • Assay validation with proven pharmacologically active compounds
  • Repurposing/ repositioning: A useful tool for researching new targets of marketed drugs
  • Start of new optimization process
  • Finding of stem cell growth modulators
  • Others…to come


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