Prestwick Drug-Fragment Library

1456 fragments arising from smart
fragmentationof approved drugs

Acknowledged as powerful tool for successful identification of lead series, fragment-based drug design is widely implemented in industry and academia. To meet researchers’ expectations, Prestwick Chemical medicinal chemists have designed a unique collection of 1456 small molecules (MW<300) arising from the smart fragmentation of approved drugs (up to year 2016).

 

Key features

Good coverage of lead-like diversity space
High-quality hit increased by using fragments derived from approved drugs
Rapid follow-up on primary hits possible
Experimental solubility in DMSO (100 mM) and PBS (1 mM) available
Purity 95%+ (H NMR spectrum and LC/MS available)
Balanced set of Ro3 compliant (55%) and Ro3 non-compliant (45%) fragments – Mean MW: 182
56% are exclusive to the Prestwick Drug-Fragment Library and cannot be found in any other major supplier of fragment libraries

How provided?

 

Format Comments
Core set
480 cpds
  • DMSO solution (up to 100 mM)
  • NEW : DMSO-d6 solution
    (up to 100 mM)
Representative set of the entire library
Ready for Screening
Highly recommanded for rapid outcomes
Complete library
  • Undissolved (>10 mg)
Available for cherry picking
Customized
set
  • Undissolved (>10 mg)
  • DMSO solution (up to 100 mM)
Selection based on your own criteria
(physicochemical properties, substructure or similary search)
Re-supply guaranteed

 

Application

  • Fragment screening (X-ray crystallography, NMR, SPR, high concentration bioassay, …)
  • HTS for small molecules

 

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