CITATIONS

Prestwick Chemical

650+ Clients Worldwide
Success stories

350+ publications mentioning the Prestwick Chemical Library®





Jihu Dong, J., Aulestia, F.J., Kahn, S.A., Zeniou, M., Haiech, J., Kilhoffer, M.C.
Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, In Press
http://dx.doi.org/10.1016/j.bbamcr.2017.01.010

Varbanov, H.P., Kuttler, F., Banfi, D., Turcatti, G., Dyson, P.J.
Repositioning approved drugs for the treatment of problematic cancers using a screening approach. PLoS ONE, 2017, 12(2), e0171052
http://dx.doi.org/10.1371/journal.pone.0171052

Tournu, H., Carroll, J., Latimer, B., Dragoi, A.M., Dykes, S., Cardelli, J., Peters, T.L., Eberle, K.E., Palmer, G.E.
Identification of small molecules that disrupt vacuolar function in the pathogen Candida albicans. PLoS ONE, 2017, 12(2), e0171145
http://dx.doi.org/10.1371/journal.pone.0171145

Levoin, N., Labeeuw, O., Billot, X., Calmels, T., Danvy, D., Krief, S., Berrebi-Bertrand, I., Lecomte, J.M., Schwartz J.C., Caper, M.
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening. European Journal of Medicinal Chemistry, 2017, 125, 5, 565–572
http://dx.doi.org/10.1016/j.ejmech.2016.09.074

Neira, J.L., Bintz, J., Arruebo, M., Rizzuti, B., Bonacci, T., Vega, S., Lanas, A., Velázquez-Campoy, A., Iovanna, J.L., Abián, O.
Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma. Sci Rep, 2017, 7, 39732
http://www.nature.com/articles/srep39732

Messer, J., Cham, C., Zhu, X., Patno, N.; Tao, Y., Chang, E.
PD-235 Targeting HMGB1-dependent Survival and Energy Production Pathways to Improve Mucosal Healing during IBD. Inflammatory Bowel Diseases, Official Journal of the Crohn’s & Colitis Foundation of America, 2017, S77, PD-235
http://journals.lww.com/ibdjournal/Abstract/2017(...)

Tsai, S.Y., Chen, S., Evans, T.
Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling. Curr. Protoc. Stem Cell Biol. 2017, 40:1F.16.1-1F.16.13
http://onlinelibrary.wiley.com/doi/10.1002/cpsc.20/abstract

Villacé, P., Mella, R.M., Roura-Ferrer, M., Valcarcel, M., Salado, C., Castilla, A., Kortazar, D.
Fluorescent Parkin Cell-Based Assay Development for the Screening of Drugs against Parkinson Disease.SLAS Discovery, Advancing Life Sciences R&D, 2017, 22, 1, 67–76
https://doi.org/10.1177/1087057116671498

Kel, A.E., Stegmaier, P., Koschmann, J., Poroikov, V., Kel-Margoulis, O.V., Wingender, E.
Multi-omics “upstream analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer. EuPA Open Proteomics, 2016, 13, 1–13
http://dx.doi.org/10.1016/j.euprot.2016.09.002
López-García, I., Gerő, D., Szczesny, B., Szoleczky, P., Olah, G., Módis, K., Zhang, K., Gao, J., Wu, P., Sowers, L. C., DeWitt, D., Prough, D. S., Szabo, C.
Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant. British Journal of Pharmacology, 2016
http://onlinelibrary.wiley.com/doi/10.1111/bph.13642/full

Seol, H.S., Lee, S.E., Song, J.E., Lee H.Y., Park, S., Kim, I., Singh, S.R., Chang, S., Jang, S.J.
Glutamate release inhibitor, Riluzole, inhibited proliferation of human hepatocellular carcinoma cells by elevated ROS production. Cancer Letters, 2016, 382, 2, 157–165
http://dx.doi.org/10.1016/j.canlet.2016.08.028

Nylén, F., Bergman, P., Gudmundsson, G.H., Agerberth, B.
Assays for Identifying Inducers of the Antimicrobial Peptide LL-37 Antimicrobial Peptides, Protocol, 2016, volume 1548 of the series Methods in Molecular Biology, 271–281
http://link.springer.com/protocol/10.1007/978-1-4939-6737-7_19

Druzhyna, N., Szczesny, B., Plah, G., Modis, K., Asimakopoulou, A., Pavlidou, A., Papapetropoulos, A., Hellmich, M., Szabo, C.
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. Pharmacological Research, 2016, 113, Part A, 18–37
http://dx.doi.org/10.1016/j.phrs.2016.08.016

Arvidsson, P. I., Sandberg, K., Forsberg-Nilsson, K.
Open for collaboration: an academic platform for drug discovery and development at SciLifeLab. Drug Discovery Today, 2016, 21(10):1690–1698
http://doi.org/10.1016/j.drudis.2016.06.026

Bastin, J., Djouadi, F
Resveratrol and Myopathy. Nutrients, 2016, 8(5), 254
http://doi.org/10.3390/nu8050254

Cappato, S., Tonachini, L., Giacopelli, F., Tirone, M., Galietta, L. J. V., Sormani, M., Bocciardi, R.
High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva. Disease Models & Mechanisms , 2016, 9(6), 685–696
http://doi.org/10.1242/dmm.023929

Chen, G., Masuda, A., Konishi, H., Ohkawara, B., Ito, M., Kinoshita, M., Ohno, K.
Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Scientific Reports, 2016, 6(April), 25317
http://doi.org/10.1038/srep25317

Cheng, H., Chen, T., Tor, M., Park, D., Zhou, Q., Huang, J. B., Zhou, G.
A High-Throughput Screening Platform Targeting PDLIM5 for Pulmonary Hypertension. Journal of Biomolecular Screening, 2016, 21(4), 333–34
http://doi.org/10.1177/1087057115625924

Chneiweiss, H., Junier, M.-P., Etienne, V.
Recycler un anti-hypertenseur pour combattre les tumeurs du cerveau. Communiqué de Presse National, (2016, April 15), Paris
http://doi.org/10.15252/emmm.201505421

Coleman, D. T., Gray, A. L., Stephens, C. A., Scott, M. L., Cardelli, J. A.
Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation. Oncotarget, 2016, 7(22), 1–10.
http://doi.org/10.18632/oncotarget.8609

Druzhyna, N., Szczesny, B., Olah, G., Módis, K., Asimakopoulou, A., Pavlidou, A., Szabo, C.
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon. Pharmacological Research, 2016, 113, 18–37.
http://doi.org/10.1016/j.phrs.2016.08.016

Ekins, S., Mietchen, D., Coffee, M., Stratton, T., Freundlich, J., Freitas-Junior, L., Andrade, C.
Open drug discovery for the Zika virus. F1000Research, 2016, 5(0), 150.
http://doi.org/10.12688/f1000research.8013.1

Fattahi, F., Steinbeck, J. A., Kriks, S., Tchieu, J., Zimmer, B., Kishinevsky, S., Studer, L.
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature, 2016, 531(7592), 105–9.
http://doi.org/10.1038/nature16951

Gofshteyn, J., Cárdenas, A. M., Bearden, D.
Treatment of chronic enterovirus encephalitis with fluoxetine in a patient with X-linked agammaglobulinemia. Pediatric Neurology, 2016.
http://doi.org/10.1016/j.pediatrneurol.2016.06.014

Guetschow, E. D., Kumar, S., Lombard, D. B., Kennedy, R. T.
Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples. Analytical and Bioanalytical Chemistry, 2016, 408(3), 721–731.
http://doi.org/10.1007/s00216-015-9206-0

Hasegawa, S., Kitoh, H., Ohkawara, B., Mishima, K., Matsushita, M., Masuda, A., Ohno, K.
Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters. Biochemical and Biophysical Research Communications, 2016, 470(2), 356–361.
http://doi.org/10.1016/j.bbrc.2016.01.044

Holler, C. J., Taylor, G., McEachin, Z. T., Deng, Q., Watkins, W. J., Hudson, K., Kukar, T.
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Molecular Neurodegeneration, 2016, 11(1), 46.
http://doi.org/10.1186/s13024-016-0114-3
Iglesias, A., Lage, S., Cadavid, M. I., Loza, M. I., Brea, J.
Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening. Journal of Biomolecular Screening, 2016.
http://doi.org/10.1177/1087057116644162

Kang, J., Hsu, C.-H., Wu, Q., Liu, S., Coster, A. D., Posner, B. A., Wu, L. F.
Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Natural Biotechnology, 2016, 34(1), 70–77.
http://doi.org/10.1038/nbt.3419

Koppel, J., Jimenez, H., Adrien, L., Greenwald, B. S., Marambaud, P., Cinamon, E., Davies, P.
Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer’s disease. Alzheimer’s and Dementia: Translational Research and Clinical Interventions, 2016, 2(2), 121–130.
http://doi.org/10.1016/j.trci.2016.05.003

López, L. C., Varea, O., Navarro, S., Carrodeguas, J. A., Sanchez de Groot, N., Ventura, S., Sancho, J.
Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation. International Journal of Molecular Sciences, 2016, 17(6).
http://doi.org/10.3390/ijms17060964

Nogueira, U., Dominguez, E., Loza, M. I., Blanco, F. J., Carames, B.
Identification of novel molecules targeting cartilage aging as osteoarthritis therapeutics. Osteoarthritis and Cartilage, 2016, 24, S18–S19.
http://doi.org/10.1016/j.joca.2016.01.062

Prado, S., Beltrán, M., Coiras, M., Bedoya, L. M., Alcamí, J., Gallego, J.
Bioavailable inhibitors of HIV-1 RNA biogenesis identified through a Rev-based screen. Biochemical Pharmacology, 2016, 107, 14–28.
http://doi.org/10.1016/j.bcp.2016.02.007

Rhim, J. heon, Luo, X., Gao, D., Xu, X., Zhou, T., Li, F., Xia, X.
Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells. Scientific Reports, 2016, 6(May), 26547.
http://doi.org/10.1038/srep26547

Sakano, D., Choi, S., Kataoka, M., Shiraki, N., Uesugi, M., Kume, K., Kume, S.
Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass. Stem Cell Reports, 2016, 7(1), 95–109.
http://doi.org/10.1016/j.stemcr.2016.05.015

Samantaray, S., Correia, J. N., Garelnabi, M., Voelz, K., May, R. C., Hall, R. A.
Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages. International Journal of Antimicrobial Agents, 2016, 48(1), 69–77.
http://doi.org/10.1016/j.ijantimicag.2016.04.018

Shah, E. T., Upadhyaya, A., Philp, L. K., Tang, T., Skalamera, D., Gunter, J., Hollier, B. G.
Repositioning “old” drugs for new causes: identifying new inhibitors of prostate cancer cell migration and invasion. Clinical & Experimental Metastasis, 2016, 33(4), 385–399.
http://doi.org/10.1007/s10585-016-9785-y

Timiri Shanmugam, P. S., Nair, R. P., De Benedetti, A., Caldito, G., Abreo, F., Sunavala-Dossabhoy, G.
Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells. Free Radical Biology and Medicine, 2016, 93, 217–226.
http://doi.org/10.1016/j.freeradbiomed.2015.12.029

Torres, N. S., Abercrombie, J. J., Srinivasan, A., Lopez-Ribot, J. L., Ramasubramanian, A. K., Leung, K. P.
Screening a Commercial Library of Pharmacologically Active Small Molecules Against Staphylococcus aureus Biofilms. Antimicrobial Agents and Chemotherapy, 2016, July, AAC.00377-16.
http://doi.org/10.1128/AAC.00377-16

Ulferts, R., de Boer, S. M., van der Linden, L., Bauer, L., Lyoo, H. R., Maté, M. J., van Kuppeveld, F. J. M.
Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C. Antimicrobial Agents and Chemotherapy, 2016, 60(5), 2627–38.
http://doi.org/10.1128/AAC.02182-15

Aggarwal, C., Jimenez, J. C., Lee, H., Chlipala, G. E., Ratia, K., Federle, M. J.
Identification of quorum-sensing inhibitors disrupting signaling between Rgg and short hydrophobic peptides in streptococci. mBio, 2016, 6(3), 1–11.
http://doi.org/10.1128/mBio.00393-15

Ai, N., Wood, R. D., Welsh, W. J.
Identification of Nitazoxanide as a Group I Metabotropic Glutamate Receptor Negative Modulator for the Treatment of Neuropathic Pain: An In Silico Drug Repositioning Study. Pharmaceutical Research, 2015, 32(8), 2798–807.
http://doi.org/10.1007/s11095-015-1665-7

Bergamo, A., Riedel, T., Dyson, P. J., Sava, G.
Preclinical combination therapy of the investigational drug NAMI-A+ with doxorubicin for mammary cancer. Investigational New Drugs, 2015, 33(1), 53–63.
http://doi.org/10.1007/s10637-014-0175-5

Bharadwaj U., Eckols T., Kolosov M., Kasembeli T., Adam A., Torres D., Zhang X., Dobrolecki L., Wei Wei, Michael T. Lewis, Bhuvanesh Dave, Jenny C. Chang, Melissa D. Landis, Chad J. Creighton, M. A., Mancini, and D. J. T.
DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER. Oncogene, 2015, 34(11), 1341–1353.
http://doi.org/10.1038/onc.2014.72

Ch’ng, J.-H., Moll, K., Quintana, M. del P., Chan, S., Moles, E., Liu, J., Wahlgren, M.
Cell-based Screening Identifies a Rosette-Disrupting Antimalarial for the Treatment of Plasmodium falciparum Malaria Complications. Blood, 2015, (February), 1–13.
http://doi.org/10.1038/srep29317
Cheung, L., Yu, D. M. T., Neiron, Z., Failes, T. W., Arndt, G. M., Fletcher, J. I.
Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen. Biochemical Pharmacology, 2015, 93(3), 380–388.
http://doi.org/10.1016/j.bcp.2014.11.006

Corbel, C., Zhang, B., Le Parc, A., Baratte, B., Colas, P., Couturier, C., Bach, S.
Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation. Chemistry and Biology, 2015, 22(4), 472–482.
http://doi.org/10.1016/j.chembiol.2015.03.009

Demishtein, A., Porat, Z., Elazar, Z., Shvets, E.
Applications of flow cytometry for measurement of autophagy. Methods, 2015, 75, 87–95.
http://doi.org/10.1016/j.ymeth.2014.12.020

Diener, S., Schorpp, K., Strom, T.-M., Hadian, K., Lorenz-Depiereux, B.
Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling. ASSAY and Drug Development Technologies, 2015, 13(8), 476–487.
http://doi.org/10.1089/adt.2015.653

Diener, S., Schorpp, K., Strom, T., Hadian, K., Lorenz-depiereux, B., Mu, H.,
Universita, T. Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling. ASSAY and Drug Development Technologies, 2015, (October), 476–487.
http://doi.org/10.1089/adt.2015.653

Divorty, N., Mackenzie, A. E., Nicklin, S. A., Milligan, G.
G protein-coupled receptor 35: An emerging target in inflammatory and cardiovascular disease. Frontiers in Pharmacology, 2015, 6(MAR), 1–13.
http://doi.org/10.3389/fphar.2015.00041

Grover, P., Shi, H., Baumgartner, M., Camacho, C. J., Smithgall, T. E.
Fluorescence polarization screening assays for small molecule allosteric modulators of ABL kinase function. PLOS ONE, 2015, 10(7), 1–26.
http://doi.org/10.1371/journal.pone.0133590

Huynh, T. P., Barwe, S. P., Lee, S. J., McSpadden, R., Franco, O. E., Hayward, S. W., Rajasekaran, A. K.
Glucocorticoids Suppress Renal Cell Carcinoma Progression by Enhancing Na,K-ATPase Beta-1 Subunit Expression. PLOS ONE, 2015 10(4), e0122442.
http://doi.org/10.1371/journal.pone.0122442

Keillor, J. W., Apperley, K. Y. P., Akbar, A.
Inhibitors of tissue transglutaminase. Trends in Pharmacological Sciences, 2015, 36(1), 32–40.
http://doi.org/10.1016/j.tips.2014.10.014

Lasserre, J.-P., Dautant, A., Aiyar, R. S., Kucharczyk, R., Glatigny, A., Tribouillard-Tanvier, D., di Rago, J.-P.
Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies. Disease Models & Mechanisms, 2015, 8(6), 509–526.
http://doi.org/10.1242/dmm.020438

Malergue, F., van Agthoven, a., Scifo, C., Egan, D., Strous, G. J.
Automation of a Phospho-STAT5 Staining Procedure for Flow Cytometry for Application in Drug Discovery. Journal of Biomolecular Screening, 2015, 20(3), 416–421.
http://doi.org/10.1177/1087057114555477

Nath, A. K., Ryu, J. H., Jin, Y. N., Roberts, L. D., Dejam, A., Gerszten, R. E., Peterson, R. T.
PTPMT1 inhibition lowers glucose through succinate dehydrogenase phosphorylation. Cell Reports, 2015, 10(5), 694–701.
http://doi.org/10.1016/j.celrep.2015.01.010

Oprea, T. I., Sklar, L. A., Agola, J. O., Guo, Y., Silberberg, M., Roxby, J. Wandinger-Ness, A.
Novel activities of select NSAID renantiomers against Rac1 and Cdc42 GTPases. PLOS ONE, 2015, 10(11), 1–32.
http://doi.org/10.1371/journal.pone.0142182

Park, C. Y., Zhou, E. H., Tambe, D., Chen, B., Lavoie, T., Dowell, M., Krishnan, R.
High-throughput screening for modulators of cellular contractile force. Integrative Biology : Quantitative Biosciences from Nano to Macro, 2015, 7(10), 1–16.
http://doi.org/10.1039/c5ib00054h

Pedram Fatemi, R., Salah-Uddin, S., Modarresi, F., Khoury, N., Wahlestedt, C., Faghihi, M. A.
Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. Journal of Biomolecular Screening, 2015, 20(9), 1132–41.
http://doi.org/10.1177/1087057115594187

Porcu, G., Serone, E., De Nardis, V., Di Giandomenico, D., Lucisano, G., Scardapane, M., Ragnini-Wilson, A.
Clobetasol and halcinonide act as smoothened agonists to promote myelin gene expression and RxRγ receptor activation. PLOS ONE, 2015, 10(12), 1–22.
http://doi.org/10.1371/journal.pone.0144550

Preuett, B., Leeder, J. S., Abdel-Rahman, S.
Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans. Journal of Biomolecular Screening, 2015, 20(9), 1171–1177.
http://doi.org/10.1177/1087057115594751

Raneri, M., Sciandrone, B., Briani, F.
A whole-cell assay for specific inhibitors of translation initiation in bacteria. Journal of Biomolecular Screening, 2015, 20(5), 627–33.
http://doi.org/10.1177/1087057114566376

Ratajewski, M., Grzelak, I., Wisniewska, K., Ryba, K., Gorzkiewicz, M., Walczak-Drzewiecka, A., Dastych, J.
Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicology Letters, 2015, 232(1), 193–202.
http://doi.org/10.1016/j.toxlet.2014.10.009
Rauthan, M., Pilon, M.
A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. Elegans. Worm, 2015, 4(4), e1096490.
http://doi.org/10.1080/21624054.2015.1096490

Ren, X.-R., Wang, J., Osada, T., Mook, R. A., Morse, M. A., Barak, L. S., Chen, W.
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. Breast Cancer Research, 2015, 17(20), 1–11.
http://doi.org/10.1186/s13058-015-0528-9

Rybniker, J., Vocat, A., Sala, C., Busso, P., Pojer, F., Benjak, A., Cole, S. T.
Lansoprazole is an antituberculous prodrug targeting cytochrome bc1. Nature Communications, 2015, 6(7659), 1–8.
http://doi.org/10.1038/ncomms8659

Seguin, A., Monnier, V. V., Palandri, A., Bihel, F. F., Rera, M., Schmitt, M., Lesuisse, E.
A Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency. Oxidative Medicine and Cellular Longevity, 2015, ID 565140, 1–11.
http://doi.org/10.1155/2015/565140

Srivastava, G., Matta, A., Fu, G., Somasundaram, R. T., Datti, A., Walfish, P. G., Ralhan, R.
Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy. Molecular Oncology, 2015, 9, 1720–1735.
http://doi.org/10.1016/j.molonc.2015.05.005

Stolp, Z. D., Smurthwaite, C. A., Reed, C., Williams, W., Dharmawan, A., Djaballah, H., Wolkowicz, R.
A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane Processing as a Target against Dengue Virus. Journal of Biomolecular Screening, 2015, 20(5), 616–26.
http://doi.org/10.1177/1087057115571247

Takeuchi, M., Yamamoto, T.
Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Experimental Cell Research, 2015, 335(1), 62–67.
http://doi.org/10.1016/j.yexcr.2015.05.019

Teixeira-Castro, A., Jalles, A., Esteves, S., Kang, S., Da Silva Santos, L., Silva-Fernandes, A., Maciel, P.
Serotonergic signaling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain, 2015, 138, 3221–3237.
http://doi.org/10.1093/brain/awv262

Tsai, S. Y., Maass, K., Lu, J., Fishman, G. I., Chen, S., Evans, T.
Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling. Stem Cell Reports, 2015, 4, 1089–1102.
http://doi.org/10.1016/j.stemcr.2015.04.015

Vidalain, P., Lucas-hourani, M.
Activation de la réponse innée antivirale par des inhibiteurs de la biosynthèse des pyrimidines Les surprises d’un criblage, Med Sci, 2015, 30(4), 98–104.

Wasko, M. J., Pellegrene, K. A., Madura, J. D., Surratt, C. K.
A role for fragment-based drug design in developing novel lead compounds for central nervous system targets. Frontiers in Neurology, 2015, 6(SEP), 1–11.
http://doi.org/10.3389/fneur.2015.00197

Watari, A., Hashegawa, M., Muangman, T., Yagi, K., Kondoh, M.
Use of cell-based screening to identify small-molecule compounds that modulate claudin-4 expression. Biotechnology Letters, 2015, 37, 1177–1185.
http://doi.org/10.1007/s10529-015-1791-7

Yi, N. Y., He, Q., Caligan, T. B., Smith, G. R., Forsberg, L. J., Brenman, J. E., Sexton, J. Z.
Development of a Cell-Based Fluorescence Polarization Biosensor Using Preproinsulin to Identify Compounds That Alter Insulin Granule Dynamics. Assay and Drug Development Technologies, 2015, 13(9), 558–569.
http://doi.org/10.1089/adt.2015.665

Zeniou, M., Fève, M., Mameri, S., Dong, J., Salomé, C., Chen, W., Heeschen, C.
Chemical library screening and structure-function relationship studies identify bisacodyl as a potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like cells. PLOS ONE, 2015, 1–35.
http://doi.org/10.1371/journal.pone.0134793

Ahn, H. J., Glickman, J. F., Poon, K. L., Zamolodchikov, D., Jno-Charles, O. C., Norris, E. H., Strickland, S.
A novel A-beta-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice. J. Exp. Med. , 2014, 211(6), 1049–1062.

Aiyar, R. S., Bohnert, M., Duvezin-Caubet, S., Voisset, C., Gagneur, J., Fritsch, E. S., Steinmetz, L. M.
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders. Nature Communications, 2014, 5(5585), 1–9.
http://doi.org/10.1038/ncomms6585

Alekseev, S., Ayadi, M., Brino, L., Egly, J. M., Larsen, A. K., & Coin, F.
A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the Chemosensitization of tumor cells to platinum. Chemistry and Biology, 2014, 21, 398–407.
http://doi.org/10.1016/j.chembiol.2013.12.014

Allali-Hassani, A., Kuznetsova, E., Hajian, T., Wu, H., Dombrovski, L., Li, Y., Vedadi, M. A
Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro. Journal of Biomolecular Screening, 2014, 19(6), 928–935.
http://doi.org/10.1177/1087057114525854

Andreux, P. a, Mouchiroud, L., Wang, X., Jovaisaite, V., Mottis, A., Bichet, S., Auwerx, J.
A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. Elegans. Scientific Reports, 2014, 4(5285), 1–10.
http://doi.org/10.1038/srep05285
Baell, J., Walters, M. A.
Chemical con artists foil drug discovery. Nature, 2014, 513, 481–483.
http://doi.org/10.1038/513481a

Balsera, B., Mulet, J., Fernández-Carvajal, A., Torre-Martínez, R. D. La, Ferrer-Montiel, A., Hernández-Jiménez, J. G., Criado, M.
Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure. European Journal of Medicinal Chemistry, 2014, 86, 724–739.
http://doi.org/10.1016/j.ejmech.2014.09.039

Bernardo, S. M., Allen, C. P., Waller, A., Young, S. M., Oprea, T., Sklar, L. A., Lee, S. A.
An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicansvirulence-related proteins. PLOS ONE, 2014, 9(10; e110354), 1–11.
http://doi.org/10.1371/journal.pone.0110354

Bharadwaj, U., Eckols, T. K., Kolosov, M., Kasembeli, M. M., Adam, a, Torres, D., Tweardy, D. J.
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene, 2014, 34, 1341–1353
http://doi.org/10.1038/onc.2014.72

Bhuvanagiri, M., Lewis, J., Putzker, K., Becker, J. P., Leicht, S., Krijgsveld, J., Kulozik, A. E.
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion. EMBO Molecular Medicine, 2014, 6(12), 1593–1609.
http://doi.org/10.15252/emmm.201404461

Blatt, J., Farag, S., Corey, S. J., Sarrimanolis, Z., Muratov, E., Fourches, D., Janzen, W. P.
Expanding the scope of drug repurposing in pediatrics: the Children’s Pharmacy Collaborative Drug Discovery Today, 2014, 19(11), 1696–1698.
http://doi.org/10.1016/j.drudis.2014.08.003

Chang, Q., Berdyshev, E., Cao, D., Bogaard, J. D., White, J. J., Chen, S., Grassi, M. A.
Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors. Journal of Biological Chemistry, 2014, 289(12), 8337–8352.
http://doi.org/10.1074/jbc.M113.507152

Denicolaï, E., Baeza-Kallee, N., Tchoghandjian, A., Carré, M., Colin, C., Jiglaire, C. J., Figarella-Branger, D. Proscillaridin.
A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo. Oncotarget, 2014, 5(21), 10934–10948.
http://doi.org/10.18632/oncotarget.2541

Donohue, E., Balgi, A. D., Komatsu, M., Roberge, M.
Induction of covalently crosslinked p62 oligomers with reduced binding to polyubiquitinated proteins by the autophagy inhibitor verteporfin. PLOS ONE, 2014, 9(12), 1–30.
http://doi.org/10.1371/journal.pone.0114964

Filgueira, C. S., Benod, C., Lou, X., Gunamalai, P. S., Villagomez, R. A., Strom, A., Webb,
P. A screening cascade to identify ERβ ligands. Nuclear Receptor Signaling, 2014, 12, 1–13.
http://doi.org/10.1621/nrs.12003


García-Alcover, I., Colonques-Bellmunt, J., Garijo, R., Tormo, J. R., Artero, R., Álvarez-Abril, M. C., Pérez-Alonso, M.
Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1. Disease Models & Mechanisms, 2014, 7(11), 1297–1306.
http://doi.org/10.1242/dmm.016592

Geer, M. A., Fitzgerald, M. C.
Energetics-based methods for protein folding and stability measurements. Annual Review of Analytical Chemistry (Palo Alto, Calif.) , 2014, 7(1), 209–28.
http://doi.org/10.1146/annurev-anchem-071213-020024

Gutierrez, A., Pan, L., Groen, R. W. J., Baleydier, F., Kentsis, A., Marineau, J., Aster, J. C.
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. Journal of Clinical Investigation, 2014, 124(2), 644–655.
http://doi.org/10.1172/JCI65093

Hall, C. J., Wicker, S. M., Chien, A.-T., Tromp, A., Lawrence, L. M., Sun, X., Crosier, P. S.
Repositioning drugs for inflammatory disease-fishing for new anti-inflammatory agents. Disease Models & Mechanisms, 2014, 7, 1069–1081.
http://doi.org/10.1242/dmm.016873

Kawahara, G., Gasperini, M. J., Myers, J. A., Widrick, J. J., Eran, A., Serafini, P. R., Kunkel, L. M.
Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Human Molecular Genetics, 2014, 23(7), 1869–1878.
http://doi.org/10.1093/hmg/ddt579

Liu, C., Lou, W., Zhu, Y., Nadiminty, N., Schwartz, C. T., Evans, C. P., Gao, A. C.
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer. Clinical Cancer Research 2014, (Vol. 20).
http://doi.org/10.1158/1078-0432.CCR-13-3296

Mech, L. D.
Chemical Genetic Identification of the Histamine H1 Receptor as a Stimulator of Insulin-Induced Adipogenesis. Chemistry & Biology, 2014 11, 907–913.
http://doi.org/10.1016/j

Meneely, K. M., Luo, Q., Riley, A. P., Taylor, B., Roy, A., Stein, R. L., Lamb, A. L.
Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorganic and Medicinal Chemistry, 2014, 22, 5961–5969.
http://doi.org/10.1016/j.bmc.2014.09.010
Normand, A., Rivière, E., Renodon-Cornière, A.
Identification and characterization of human Rad51 inhibitors by screening of an existing drug library. Biochemical Pharmacology, 2014, 91, 293–300.
http://doi.org/10.1016/j.bcp.2014.07.033

Nylén, F., Miraglia, E., Cederlund, A., Ottosson, H., Strömberg, R., Gudmundsson, G. H., Agerberth, B.
Boosting innate immunity: Development and validation of a cell-based screening assay to identify LL-37 inducers. Innate Immunity, 2014, 20(4), 364–376.
http://doi.org/10.1177/1753425913493338

Patten, S. a, Armstrong, G. a B., Lissouba, A., Kabashi, E., Parker, J. A., & Drapeau, P.
Fishing for causes and cures of motor neuron disorders. Disease Models & Mechanisms, 2014, 7, 799–809.
http://doi.org/10.1242/dmm.015719

Pytel, D., Seyb, K., Liu, M., Ray, S. S., Concannon, J., Huang, M., Glicksman, M. A.
Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen, 2014, 2(2), 1024–1034.
http://doi.org/10.14440/jbm.2015.54.A

Röhrig, U. F., Majjigapu, S. R., Chambon, M., Bron, S., Pilotte, L., Colau, D., Michielin, O.
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. European Journal of Medicinal Chemistry, 2014, 84, 284–301.
http://doi.org/10.1016/j.ejmech.2014.06.078

Tegos, G. P., Evangelisti, A. M., Strouse, J. J., Ursu, O., Bologa, C., Sklar, L. A.
A high throughput flow cytometric assay platform targeting transporter inhibition. Drug Discovery Today: Technologies, 2014, 12, e95–e103.
http://doi.org/10.1016/j.ddtec.2014.03.010

Theorell, J., Gustavsson, A. L., Tesi, B., Sigmundsson, K., Ljunggren, H. G., Lundbäck, T., Bryceson, Y. T.
Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation. Cancer Immunology, Immunotherapy, 2014, 63, 627–641.
http://doi.org/10.1007/s00262-014-1539-6

Voisset, C., Daskalogianni, C., Contesse, M.-A., Mazars, A., Arbach, H., Le Cann, M., Blondel, M.
A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus. Disease Models & Mechanisms, 2014, 7, 435–444.
http://doi.org/10.1242/dmm.014308

Voisset, C., García-Rodríguez, N., Birkmire, A., Blondel, M., Wellinger, R. E.
Using yeast to model calcium-related diseases: Example of the Hailey-Hailey disease. Biochimica et Biophysica Acta - Molecular Cell Research, 2014, 1843(10), 2315–2321.
http://doi.org/10.1016/j.bbamcr.2014.02.011

Walzl, A., Unger, C., Kramer, N., Unterleuthner, D., Scherzer, M., Hengstschläger, M., Dolznig, H.
The Resazurin Reduction Assay Can Distinguish Cytotoxic from Cytostatic Compounds in Spheroid Screening Assays. Journal of Biomolecular Screening, 2014, 19(7), 1047–1059.
http://doi.org/10.1177/1087057114532352

Wang, J., Cheng, H., Ratia, K., Varhegyi, E., Hendrickson, W. G., Li, J., Rong, L.
A Comparative High-Throughput Screening Protocol to Identify Entry Inhibitors of Enveloped Viruses. Journal of Biomolecular Screening, 2014, 19(1), 100–107.
http://doi.org/10.1177/1087057113494405

Wolter, J. K., Wolter, N. E., Blanch, A., Partridge, T., Cheng, L., Morgenstern, D. A., Irwin, M. S.
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. Oncotarget, 2014, 5(1), 161–172.
http://doi.org/10.18632/oncotarget.1083

Yang, Y. H. C., Vilin, Y. Y., Roberge, M., Kurata, H. T., Johnson, J. D.
Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death. Molecular Endocrinology, 2014, 28(3), 406–417.
http://doi.org/10.1210/me.2013-1257

Zhang, M., Luo, G., Zhou, Y., Wang, S., Zhong, Z.
Phenotypic Screens Targeting Neurodegenerative Diseases. Journal of Biomolecular Screening, 2014, 19(1), 1–16.
http://doi.org/10.1177/1087057113499777

Podolska, K., Sedlak, D., Bartunek, P., Svoboda, P.
Fluorescence-Based High-Throughput Screening of Dicer Cleavage Activity. Journal of Biomolecular Screening, 2014, 19(3), 417–426.
http://doi.org/10.1177/1087057113497400

Ahmad, S., Hughes, M. a, Johnson, G. L., Scott, J. E.
Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors. Journal of Biomolecular Screening, 2013, 18(4), 388–399.
http://doi.org/10.1177/1087057112466430

Antoniani, D., Rossi, E., Rinaldo, S., Bocci, P., Lolicato, M., Paiardini, A., Landini, P.
The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability. Applied Microbiology and Biotechnology 2013, 97, 7325–7336.
http://doi.org/10.1007/s00253-013-4875-0

Audran, E., Dagher, R., Gioria, S., Tsvetkov, P. O., Kulikova, A. A., Didier, B., Haiech, J.
A general framework to characterize inhibitors of calmodulin: Use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains. Biochimica et Biophysica Acta - Molecular Cell Research, 2013, 1833(7), 1720–1731.
http://doi.org/10.1016/j.bbamcr.2013.01.008
Bharat, A., Blanchard, J. E., Brown, E. D.
A high-throughput screen of the GTPase activity of Escherichia coli EngA to find an inhibitor of bacterial ribosome biogenesis. Journal of Biomolecular Screening, 2013, 18(7), 830–836.
http://doi.org/10.1177/1087057113486001

Blatt, J., Corey, S. J.
Drug repurposing in pediatrics and pediatric hematology oncology. Drug Discovery Today, 2013, 18(1–2), 4–10.
http://doi.org/10.1016/j.drudis.2012.07.009

Cederlund, A., Nylén, F., Miraglia, E., Bergman, P., Gudmundsson, G. H., Agerberth, B.
Label-Free Quantitative Mass Spectrometry Reveals Novel Pathways Involved in LL-37 Expression. Journal of Innate Immunity, 2013, 365–376.
http://doi.org/10.1159/000355931

Chartier, A., Simonelig, M.
Animal models in therapeutic drug discovery for oculopharyngeal muscular dystrophy. Drug Discovery Today: Technologies, 2013, 10, e103–e108.
http://doi.org/10.1016/j.ddtec.2012.07.002

Choulier, L., Nominé, Y., Zeder-Lutz, G., Charbonnier, S., Didier, B., Jung, M. L., Altschuh, D.
Chemical library screening using a SPR-based inhibition in solution assay: Simulations and experimental validation. Analytical Chemistry, 2013, 85, 8787–8795.
http://doi.org/10.1021/ac4019445

Dahlin, J. L., Sinville, R., Solberg, J., Zhou, H., Han, J., Francis, S., Zhang, Z.
A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation. PLOS ONE, 2013, 8(11).
http://doi.org/10.1371/journal.pone.0078877

Goldman, R. C.
Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis? Tuberculosis, 2013, 93, 569–588.
http://doi.org/10.1016/j.tube.2013.09.003

Gozalbes, R., Mosulén, S., Ortí, L., Rodríguez-Díaz, J., Carbajo, R. J., Melnyk, P., Pineda-Lucena, A.
Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches. Bioorganic and Medicinal Chemistry, 2013, 21, 1944–1951.
http://doi.org/10.1016/j.bmc.2013.01.033

Gupta, V. A., Kuwada, J. Y., Beggs, A. H.
P.4.11 Developing therapies for congenital myopathies by high throughput chemical screening in ryanodine receptor 1 mutant zebrafish. Neuromuscular Disorders, 2013, 23(9–10), 762–763.
http://doi.org/10.1016/j.nmd.2013.06.449

Jiang, X., Sun, L., Qiu, J. J., Sun, X., Li, S., Wang, X., Dong, S.
A Novel Application of Furazolidone: Anti-Leukemic Activity in Acute Myeloid Leukemia. PLOS ONE, 2013, 8(8-e72335), 1–9.
http://doi.org/10.1371/journal.pone.0072335

Jin, S., Sarkar, K. S., Jin, Y. N., Liu, Y., Kokel, D., Van Ham, T. J., Peterson, R. T.
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. Journal of Biomolecular Screening, 2013, 18(1), 108–115.
http://doi.org/10.1177/1087057112458153

Kawahara, G., & Kunkel, L. M.
Zebrafish based small molecule screens for novel DMD drugs. Drug Discovery Today: Technologies, 2013, 10(1), e91–e96.
http://doi.org/10.1016/j.ddtec.2012.03.001

Kourtesi, C., Ball, A. R., Huang, Y.-Y., Jachak, S. M., Vera, D. M. a, Khondkar, P., Tegos, G. P.
Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation. The Open Microbiology Journal, 2013, 7, 34–52.
http://doi.org/10.2174/1874285801307010034

Kumagai, H., Suemori, H., Uesugi, M., Nakatsuji, N., Kawase, E.
Identification of small molecules that promote human embryonic stem cell self-renewal. Biochemical and Biophysical Research Communications, 2013, 434, 710–716.
http://doi.org/10.1016/j.bbrc.2013.03.061

Liu, M., Lin, Y. ling, Chen, X. R., Liao, C. C., Poo, W. K.
In vitro assessment of Macleaya cordata crude extract bioactivity and anticancer properties in normal and cancerous human lung cells. Experimental and Toxicologic Pathology, 2013, 65, 775–787.
http://doi.org/10.1016/j.etp.2012.11.004

McCormick, A. V., Wheeler, J. M., Guthrie, C. R., Liachko, N. F., Kraemer, B. C.
Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biological Psychiatry, 2013, 73, 464–471.
http://doi.org/10.1016/j.biopsych.2012.08.027

Ozawa, M., Shimojima, M., Goto, H., Watanabe, S., Hatta, Y., Kiso, M., Kawaoka, Y.
A cell-based screening system for influenza A viral RNA transcription/replication inhibitors. Scientific Reports, 3, 2013, 1106.
http://doi.org/10.1038/srep01106

Reipas, K. M., Law, J. H., Couto, N., Islam, S., Li, Y., Li, H., Dunn, S. E.
Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget, 2013, 4(2), 329–345.
http://doi.org/10.18632/oncotarget.834 Robinson, T. J. W., Liu, J. C., Vizeacoumar, F., Sun, T., Maclean, N., Egan, S. E., Zacksenhaus, E.
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLOS ONE, 2013, 8(11).
http://doi.org/10.1371/journal.pone.0078641
Sadikot, T., Swink, M., Eskew, J. D., Brown, D., Zhao, H., Kusuma, B. R., Vielhauer, G. A.
Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay and Drug Development Technologies, 2013, 11(8), 478–488.
http://doi.org/10.1089/adt.2012.498

Salani, B., Marini, C., Rio, A. Del, Ravera, S., Massollo, M., Orengo, A. M., Sambuceti, G.
Metformin impairs glucose consumption and survival in Calu-1 cells by direct inhibition of hexokinase-II. Scientific Reports, 2013, 3 (2070), 1–8.
http://doi.org/10.1038/srep02070

Shanks, E. J.
Reduce, reuse, recycle: How drug repositioning is finding its niche in drug discovery. European Pharmaceutical Review, 2013, 18(3), 31–34.

Siles, S. A., Srinivasan, A., Pierce, C. G., Lopez-Ribot, J. L., Ramasubramanian, A. K.
High-throughput screening of a collection of known pharmacologically active small compounds for identification of candida albicans biofilm inhibitors. Antimicrobial Agents and Chemotherapy, 2013, 57(8), 3681–3687.
http://doi.org/10.1128/AAC.00680-13

Wrench, A. P., Gardner, C. L., Gonzalez, C. F., Lorca, G. L.
Identification of a Small Molecule That Modifies MglA/SspA Interaction and Impairs Intramacrophage Survival of Francisella tularensis. PLOS ONE, 2013, 8(1 (e54498)), 1–14.
http://doi.org/10.1371/journal.pone.0054498

Zeder-Lutz, G., Renau-Ferrer, S., Aguié-Béghin, V., Rakotoarivonina, H., Chabbert, B., Altschuh, D., Rémond, C.
Novel surface-based methodologies for investigating GH11 xylanase-lignin derivative interactions. The Analyst, 2013, 138(22), 6889–99.
http://doi.org/10.1039/c3an00772c

Zeidler, U., Bougnoux, M. E., Lupan, A., Helynck, O., Doyen, A., Garcia, Z., d’Enfert, C.
Synergy of the antibiotic colistin with echinocandin antifungals in candida species. Journal of Antimicrobial Chemotherapy, 2013, 68(6), 1285–1296.
http://doi.org/10.1093/jac/dks538

Ahmad, S., Hughes, M. A., Yeh, L.-A., Scott, J. E.
Potential Repurposing of Known Drugs as Potent Bacterial -Glucuronidase Inhibitors. Journal of Biomolecular Screening, 2012, 17(7), 957–965.
http://doi.org/10.1177/1087057112444927

Colliandre, L., Le Guilloux, V., Bourg, S., Morin-Allory, L.
Visual characterization and diversity quantification of chemical libraries: 2. Analysis and selection of size-independent, subspace-specific diversity indices. Journal of Chemical Information and Modeling, 2012, 52(2), 327–342.
http://doi.org/10.1021/ci200535y

Conesa, C., Doss, M. X., Antzelevitch, C., Sachinidis, A., Sancho, J., Carrodeguas, J. A.
Identification of Specific Pluripotent Stem Cell Death-Inducing Small Molecules by Chemical Screening. Stem Cell Reviews and Reports, 2012, 8, 116–127.
http://doi.org/10.1007/s12015-011-9248-4

De Chassey, B., Meyniel-Schicklin, L., Aublin-Gex, A., André, P., Lotteau, V.
New horizons for antiviral drug discovery from virus-host protein interaction networks. Current Opinion in Virology, 2012, 2(5), 606–613.
http://doi.org/10.1016/j.coviro.2012.09.001

Ding, Z., German, P., Bai, S., Feng, Z., Gao, M., Si, W., Jonasch, E.
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. Journal of Biomolecular Screening, 2012, 17(5), 572–580.
http://doi.org/10.1177/1087057112436557

Flusin, O., Saccucci, L., Contesto-Richefeu, C., Hamdi, A., Bardou, C., Poyot, T., Iseni, F.
A small molecule screen in yeast identifies inhibitors targeting protein-protein interactions within the vaccinia virus replication complex. Antiviral Research, 2012, 96(2), 187–195.
http://doi.org/10.1016/j.antiviral.2012.07.010

Giacomotto, J., Ségalat, L., Carre-Pierrat, M., Gieseler, K.
Caenorhabditis elegans as a chemical screening tool for the study of neuromuscular disorders. Manual and semi-automated methods. Methods, 2012, 56(1), 103–113.
http://doi.org/10.1016/j.ymeth.2011.10.010

Gupte, J., Swaminath, G., Danao, J., Tian, H., Li, Y., Wu, X.
Signaling property study of adhesion G-protein-coupled receptors. FEBS Letters, 2012, 586, 1214–1219.
http://doi.org/10.1016/j.febslet.2012.03.014

Holmes, A. R., Keniya, M. V., Ivnitski-Steele, I., Monk, B. C., Lamping, E., Sklar, L. A., Cannon, R. D.
The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial Agents and Chemotherapy, 2012, 56(3), 1508–1515.
http://doi.org/10.1128/AAC.05706-11

Li, Y.-J., Zhao, X., Vecchiarelli-Federico, L. M., Li, Y., Datti, A., Cheng, Y., Ben-David, Y.
Drug-mediated inhibition of Fli-1 for the treatment of leukemia. Blood Cancer Journal, 2012, 2(e54), 1–9.
http://doi.org/10.1038/bcj.2011.52
Libraries, O.
Drug Repurposing development strategy, 2012, 90(40), 1–8. Oprea, T. I., Mestres, J.
Drug Repurposing: Far Beyond New Targets for Old Drugs. The AAPS Journal, 2012, 14(4), 759–763.
http://doi.org/10.1208/s12248-012-9390-1

Park, S. J., Shin, J. H., Kim, E. S., Jo, Y. K., Kim, J. H., Hwang, J. J., Cho, D. H.
Mitochondrial fragmentation caused by phenanthroline promotes mitophagy. FEBS Letters, 2012, 586(24), 4303–4310.
http://doi.org/10.1016/j.febslet.2012.10.035

Polireddy, K., Khan, M. M. T., Chavan, H., Young, S., Ma, X., Waller, A., Krishnamurthy, P. A
Novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. PLOS ONE, 2012, e4005, 7, 1–14.
http://doi.org/10.1371/journal.pone.0040005

Reynolds, R. C., Ananthan, S., Faaleolea, E., Hobrath, J. V., Kwong, C. D., Maddox, C., Secrist, J. A.
High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv. Tuberculosis, 2012, 92(1), 72–83.
http://doi.org/10.1016/j.tube.2011.05.005

Sachlos, E., Risueño, R. M., Laronde, S., Shapovalova, Z., Lee, J. H., Russell, J., Bhatia, M.
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell, 2012, 149, 1284–1297.
http://doi.org/10.1016/j.cell.2012.03.049

Shin, J. H., Park, S. J., Jo, Y. K., Kim, E. S., Kang, H., Park, J. H., Cho, D. H.
Suppression of autophagy exacerbates Mefloquine-mediated cell death. Neuroscience Letters, 2012, 515, 162–167.
http://doi.org/10.1016/j.neulet.2012.03.040

Tomasini-Johansson, B. R., Johnson, I. A., Hoffmann, F. M., Mosher, D. F.
Quantitative microtiter fibronectin fibrillogenesis assay: Use in high throughput screening for identification of inhibitor compounds. Matrix Biology, 2012, 31, 360–367.
http://doi.org/10.1016/j.matbio.2012.07.003

Villalta-Romero, F., Gortat, A., Herrera, A. E., Arguedas, R., Quesada, J., De Melo, R. L., Pérez-Payá, E.
Identification of new snake venom metalloproteinase inhibitors using compound screening and rational peptide design. ACS Medicinal Chemistry Letters, 2012, 3, 540–543.
http://doi.org/10.1021/ml300068r

Walker, S. R., Frank, D. a.
Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets. Jak-Stat, 2012, 1(4), 292–299.
http://doi.org/10.4161/jkst.22662

Wang, Y., Davidow, L., Arvanites, A. C., Blanchard, J., Lam, K., Xu, K., McMahon, A. P.
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chemistry and Biology, 2012, 19(8), 972–982.
http://doi.org/10.1016/j.chembiol.2012.06.012

Zeder-Lutz, G., Choulier, L., Besse, M., Cousido-Siah, A., Figueras, F. X. R., Didier, B., Altschuh, D.
Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders. Analytical Biochemistry, 2012, 421(2), 417–427.
http://doi.org/10.1016/j.ab.2011.09.015

Ahmad, S., Hughes, M. a, Lane, K. T., Redinbo, M. R., Yeh, L.-A., Scott, J. E.
A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors. Current Chemical Genomics, 2011, 5, 13–20.
http://doi.org/10.2174/1875397301105010013

Allen, J. A., Roth, B. L.
Strategies to discover unexpected targets for drugs active at G protein-coupled receptors. Annual Review of Pharmacology and Toxicology, 2011, 51, 117–144.
http://doi.org/10.1146/annurev-pharmtox-010510-100553

Chen, M. H., Yang, W. L. R., Lin, K. T., Liu, C. H., Liu, Y. W., Huang, K. W., Huang, C. Y. F.
Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma. PLOS ONE, 2011, 6(11).
http://doi.org/10.1371/journal.pone.0027186

Chigaev, A., Wu, Y., Williams, D. B., Smagley, Y., Sklar, L. A.
Discovery of Very Late Antigen-4 (VLA-4, α4β 1 integrin) allosteric antagonists. Journal of Biological Chemistry, 2011, 286(7), 5455–5463.
http://doi.org/10.1074/jbc.M110.162636

Chopra, S., Matsuyama, K., Hutson, C., Madrid, P.
Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae. Journal of Antimicrobial Chemotherapy, 2011, 66, 1533–1536.
http://doi.org/10.1093/jac/dkr154

Couplan, E., Aiyar, R. S., Kucharczyk, R., Kabala, A., Ezkurdia, N., Gagneur, J., Blondel, M.
A yeast-based assay identifies drugs active against human mitochondrial disorders. PNAS USA, 2011, 108(29), 11989–11994.
http://doi.org/10.1073/pnas.1101478108

Dengler, M. A., Staiger, A. M., Gutekunst, M., Hofmann, U., Doszczak, M., Scheurich, P., van der Kuip, H.
Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis. PLOS ONE, 2011, 6(9).
http://doi.org/10.1371/journal.pone.0025139
Dey, R., Chen, L.
In search of allosteric modulators of α7-nAChR by solvent density guided virtual screening. Journal of Biomolecular Structure & Dynamics, 2011, 28(5), 695–715.
http://doi.org/10.1080/07391102.2011.10508600

Ekins, S., Williams, A. J., Krasowski, M. D., Freundlich, J. S.
In silico repositioning of approved drugs for rare and neglected diseases. Drug Discovery Today, 2011, 16(7–8), 298–310.
http://doi.org/10.1016/j.drudis.2011.02.016

Fonslow, B. R., Stein, B. D., Webb, K. J., Xu, T., Choi, J., Kyu, S., Iii, J. R. Y.
A High Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription Factors, 2011, 10(1), 54–56.
http://doi.org/10.1038/nmeth.2250.Digestion

Gohil, V. M., Offner, N., Walker, J. A., Sheth, S. A., Fossale, E., Gusella, J. F., Mootha, V. K.
Meclizine is neuroprotective in models of Huntington’s disease. Human Molecular Genetics, 2011, 20(2), 294–300.
http://doi.org/10.1093/hmg/ddq464

Hubert Jr, L., Lin, Y., Dion, V., Wilson, J. H.
Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells. Molecular and Cellular Biology, 2011, 31(15), 3105–3112.
http://doi.org/10.1128/MCB.05158-11

Hundeshagen, P., Hamacher-Brady, A., Eils, R., Brady, N. R.
Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy. BMC Biology, 2011, 9(1), 38.
http://doi.org/10.1186/1741-7007-9-38

Jo, Y. K., Park, S. J., Shin, J. H., Kim, Y., Hwang, J. J., Cho, D. H., Kim, J. C.
ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. Biochemical and Biophysical Research Communications, 2011, 404(4), 1039–1043.
http://doi.org/10.1016/j.bbrc.2010.12.106

Kawahara, G., Karpf, J.
Drug screening in a zebrafish model of Duchenne muscular dystrophy. Pnas, 2011, 108(13), 5331–6.
http://doi.org/10.1073/pnas.1102116108

Kawahara, G., Karpf, J. A., Myers, J. A., Alexander, M. S., Guyon, J. R., Kunkel, L. M.
Drug screening in a zebrafish model of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(13), 5331–6.
http://doi.org/10.1073/pnas.1102116108

Kumar, E. A., Charvet, C. D., Lokesh, G. L., Natarajan, A.
High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions. Analytical Biochemistry, 2011, 411(2), 254–260.
http://doi.org/10.1016/j.ab.2010.11.038

Le Guilloux, V., Colliandre, L., Bourg, S., Guénegou, G., Dubois-Chevalier, J., Morin-Allory, L.
Visual characterization and diversity quantification of chemical libraries: 1. Creation of delimited reference chemical subspaces. Journal of Chemical Information and Modeling, 2011, 51(8), 1762–1774.
http://doi.org/10.1021/ci200051r

Lee, Y. J., Burlet, E., Wang, S., Xu, B., Huang, S., Galiano, F. J., Witt, S. N.
Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochemical and Biophysical Research Communications, 2011, 414(1), 205–208.
http://doi.org/10.1016/j.bbrc.2011.09.057

MacKenzie, A. E., Lappin, J. E., Taylor, D. L., Nicklin, S. A., Milligan, G.
GPR35 as a novel therapeutic target. Frontiers in Endocrinology, 2011, 1–10.
http://doi.org/10.3389/fendo.2011.00068

Milligan, G.
Orthologue selectivity and ligand bias: Translating the pharmacology of GPR35. Trends in Pharmacological Sciences, 2011, 32(5), 317–325.
http://doi.org/10.1016/j.tips.2011.02.002

Moorwood, C., Lozynska, O., Suri, N., Napper, A. D., Diamond, S. L., Khurana, T. S.
Drug discovery for duchenne muscular dystrophy via utrophin promoter activation screening. PLOS ONE, 2011, 6(10), 1–11.
http://doi.org/10.1371/journal.pone.0026169

Peal, D. S., Mills, R. W., Lynch, S. N., Mosley, J. M., Lim, E., Ellinor, P. T., Milan, D. J.
Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen. Circulation, 2011, 123(1), 23–30.
http://doi.org/10.1161/CIRCULATIONAHA.110.003731

Sexton, J. Z., Danshina, P. V, Lamson, D. R., Hughes, M., House, A. J., Yeh, L.-A., Williams, K. P.
Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS). Current Chemical Genomics, 2011, 5, 30–41.
http://doi.org/10.2174/1875397301105010030

Spitzer, M., Griffiths, E., Blakely, K. M., Wildenhain, J., Ejim, L., Rossi, L., Wright, G. D.
Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Molecular Systems Biology, 2011, 7(1), 499.
http://doi.org/10.1038/msb.2011.31

Takakura, A., Nelson, E. A., Haque, N., Humphreys, B. D., Zandi-Nejad, K., Frank, D. A., Zhou, J.
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Human Molecular Genetics, 2011, 20(21), 4143–4154.
http://doi.org/10.1093/hmg/ddr338
Andrews, P. D., Becroft, M., Aspegren, A., Gilmour, J., James, M. J., McRae, S., Andrews, P. W.
High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules. The Biochemical Journal, 2010, 432(1), 21–33.
http://doi.org/10.1042/BJ20101022

Antoniani, D., Bocci, P., MacIa̧g, A., Raffaelli, N., & Landini, P.
Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors. Applied Microbiology and Biotechnology, 2010, 85(4), 1095–1104.
http://doi.org/10.1007/s00253-009-2199-x

Barbaric, I., Gokhale, P. J., Jones, M., Glen, A., Baker, D., & Andrews, P. W.
Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies. Stem Cell Research, 2010, 5(2), 104–119.
http://doi.org/10.1016/j.scr.2010.04.006

Buckley, C. E., Marguerie, A., Roach, A. G., Goldsmith, P., Fleming, A., Alderton, W. K., Franklin, R. J. M.
Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Neuropharmacology, 2010, 59(3), 149–159.
http://doi.org/10.1016/j.neuropharm.2010.04.014

Carme Mulero, M., Orzaez, M., Messeguer, J., Messeguer, A., Pérez-Paya, E., Pérez-Riba, M. A
Fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex. Analytical Biochemistry, 2010, 398(1), 99–103.
http://doi.org/10.1016/j.ab.2009.10.045

Colton, C. K., Kong, Q., Lai, L., Zhu, M. X., Seyb, K. I., Cuny, G. D., Glenn Lin, C.-L.
Identification of Translational Activators of Glial Glutamate Transporter EAAT2 through Cell-Based High-Throughput Screening: An Approach to Prevent Excitotoxicity. Journal of Biomolecular Screening, 2010, 15(6), 653–662.
http://doi.org/10.1177/1087057110370998

Dearmond, P. D., West, G. M., Anbalagan, V., Campa, M. J., Patz, E. F., Fitzgerald, M. C.
Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy. Journal of Biomolecular Screening, 2010, 15(9), 1051–62.
http://doi.org/10.1177/1087057110382775

Doughty-Shenton, D., Joseph, J. D., Zhang, J., Pagliarini, D. J., Kim, Y., Lu, D., Casey, P. J.
Pharmacological targeting of the mitochondrial phosphatase PTPMT1. The Journal of Pharmacology and Experimental Therapeutics, 2010 333(2), 584–92.
http://doi.org/10.1124/jpet.109.163329

Feng, R., Rios, J. A., Onishi, T., Lokshin, A., Gorelik, E., Lentzsch, S.
Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leukemia Research, 2010, 34(7), 917–924.
http://doi.org/10.1016/j.leukres.2009.12.002

Gui, C., Obaidat, A., Chaguturu, R., Hagenbuch, B.
Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Current Chemical Genomics, 2010, 4, 1–8.
http://doi.org/10.2174/1875397301004010001

Insa, R.
Drug Repositioning: Filling the Gap. European Biopharmaceutical Review, 2010 retrieved from
http://www.samedanltd.com/magazine/12/issue/132/article/2698

Jadhav, A., Ferreira, R. S., Klumpp, C., Mott, B. T., Austin, C. P., Inglese, J., Simeonov, A.
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. Journal of Medicinal Chemistry, 2010, 53(1), 37–51.
http://doi.org/10.1021/jm901070c

Jasenosky, L. D., Neumann, G., Kawaoka, Y.
Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription. Antimicrobial Agents and Chemotherapy, 54(7), 2010, 3007–3010.
http://doi.org/10.1128/AAC.00138-10

Johnson, R. M., Allen, C., Melman, S. D., Waller, A., Young, S. M., Sklar, L. A., Parra, K. J.
Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Analytical Biochemistry, 2010, 398(2), 203–211.
http://doi.org/10.1016/j.ab.2009.12.020

Kokel, D., Bryan, J., Laggner, C., White, R., Cheung, C. Y., Mateus, R., Peterson, R. T.
Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol, 2010, 6(3), 231–237.
http://doi.org/10.1038/nchembio.307

Kuhn, I., Kellenberger, E., Said-Hassane, F., Villa, P., Rognan, D., Lobstein, A., Muller-Steffner, H.
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme. Bioorganic and Medicinal Chemistry, 2010, 18(22), 7900–7910.
http://doi.org/10.1016/j.bmc.2010.09.041

Leonardi, R., Zhang, Y. M., Yun, M. K., Zhou, R., Zeng, F. Y., Lin, W., Jackowski, S.
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. Chemistry and Biology, 2010, 17(8), 892–902.
http://doi.org/10.1016/j.chembiol.2010.06.006

Lipinski, R. J., Bushman, W.
Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening. Toxicology in Vitro, 2010 24(5), 1404–1409.
http://doi.org/10.1016/j.tiv.2010.04.011
Manuscript, A., & Leads, P. D. NIH Public Access. Tuberculosis, 2010, 89(5), 331–333.
http://doi.org/10.1016/j.tube.2009.07.007.Discovery

Manuscript, A., & Syndromes, G. P. NIH Public Access, 2010, 48(Suppl 2), 1–6.
http://doi.org/10.1097/MPG.0b013e3181a15ae8.Screening

Ouertatani-Sakouhi, H., Liu, M., El-Turk, F., Cuny, G. D., Glicksman, M. A., Lashuel, H. A.
Kinetic-Based High-Throughput Screening Assay to Discover Novel Classes of Macrophage Migration Inhibitory Factor Inhibitors. Journal of Biomolecular Screening, 2010, 15(4), 347–358.
http://doi.org/10.1177/1087057110363825

Peluso, J., Muller, C. D.
Advances in flow cytometry for drug screening. Expert Opinion on Drug Discovery, 2010, 5(9), 827–833.
http://doi.org/Doi 10.1517/17460441.2010.509395

Rodgers, A. D., Zhu, H., Fourches, D., Rusyn, I., Tropsha, A., Hill, C., Carolina, N.
Modeling Liver-Related Adverse Effects of Drugs Using k Nearest Neighbor Quantitative Structure - Activity Relationship Method. Chemical Research in Toxicology, 2010, 23, 724–732.
http://doi.org/10.1021/tx900451r

Schaertl, S., Prime, M., Wityak, J., Dominguez, C., Munoz-Sanjuan, I., Pacifici, R. E., Macdonald, D.
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening, 2010, 15(5), 478–487.
http://doi.org/10.1177/1087057110366035

Shahinas, D., Liang, M., Datti, A., Pillai, D. R.
A repurposing strategy identifies novel synergistic inhibitors of plasmodium falciparum heat shock protein 90. Journal of Medicinal Chemistry, 2010, 53(9), 3552–3557.
http://doi.org/10.1021/jm901796s

Shum, D., Smith, J. L., Hirsch, A. J., Bhinder, B., Radu, C., Stein, D. A., Djaballah, H.
High-content assay to identify inhibitors of dengue virus infection. Assay and Drug Development Technologies, 2010, 8(5), 553–70.
http://doi.org/10.1089/adt.2010.0321

Talele, T. T., Arora, P., Kulkarni, S. S., Patel, M. R., Singh, S., Chudayeu, M., Kaushik-Basu, N.
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry, 2010, 18(13), 4630–4638.
http://doi.org/10.1016/j.bmc.2010.05.030

Vedadi, M., Arrowsmith, C. H., Allali-Hassani, A., Senisterra, G., Wasney, G. A.
Biophysical characterization of recombinant proteins: A key to higher structural genomics success. Journal of Structural Biology, 2010, 172(1), 107–119.
http://doi.org/10.1016/j.jsb.2010.05.005

Yeyeodu, S. T., Witherspoon, S. M., Gilyazova, N., Ibeanu, G. C.
A rapid, inexpensive high throughput screen method for neurite outgrowth. Current Chemical Genomics, 2010, 4, 74–83.
http://doi.org/10.2174/1875397301004010074

Zhao, P., Sharir, H., Kapur, A., Cowan, A., Geller, E. B., Adler, M. W., Abood, M. E.
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Molecular Pharmacology, 2010, 78(4), 560–568.
http://doi.org/10.1124/mol.110.066746

Ananthan, S., Faaleolea, E. R., Goldman, R. C., Hobrath, J. V., Kwong, C. D., Laughon, B. E., White, E. L.
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis, 89(5), 2009, 334–353.
http://doi.org/10.1016/j.tube.2009.05.008

Auld, D. S., Zhang, Y. Q., Southall, N. T., Rai, G., Landsman, M., MacLure, J., Inglese, J. A
basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry, 2009, 52(5), 1450–1458.
http://doi.org/10.1021/jm8014525

Calmels, N., Seznec, H., Villa, P., Reutenauer, L., Hibert, M., Haiech, J., Puccio, H.
Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen. BMC Neurology, 2009, 9(1), 46.
http://doi.org/10.1186/1471-2377-9-46

Charpentier, X., Gabay, J. E., Reyes, M., Zhu, J. W., Weiss, A., Shuman, H. A.
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathogens, 2009, 5(7).
http://doi.org/10.1371/journal.ppat.1000501

Chen, S., Borowiak, M., Fox, J. L., Maehr, R., Osafune, K., Davidow, L., Melton, D.
A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nature Chemical Biology, 2009, 5(4), 258–265.
http://doi.org/10.1038/nchembio.154

Conn, P. J., Jones, C. K., Lindsley, C. W.
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends in Pharmacological Sciences, 2009 30(3), 148–155.
http://doi.org/10.1016/j.tips.2008.12.002
Damoiseaux, R., Sherman, S. P., Alva, J. a, Peterson, C., Pyle, A. D.
Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells. Stem Cells, 2009, 27(3), 533–542.
http://doi.org/10.1634/stemcells.2008-0596

D’Elia, M. A., Millar, K. E., Bhavsar, A. P., Tomljenovic, A. M., Hutter, B., Schaab, C., Brown, E. D.
Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis. Chemistry and Biology, 2009, 16(5), 548–556.
http://doi.org/10.1016/j.chembiol.2009.04.009

Du, L., Damoiseaux, R., Nahas, S., Gao, K., Hu, H., Pollard, J. M., Gatti, R.
Nonaminoglycoside compounds induce readthrough of nonsense mutations. The Journal of Experimental Medicine, 2009, 206(10), 2285–2297.
http://doi.org/10.1084/jem.20081940

Ewald, J. A., Peters, N., Desotelle, J. A., Hoffmann, F. M., & Jarrard, D. F.
A High-Throughput Method to Identify Novel Senescene-Inducing Compounds. J Biomol Screen, 2009, 14(7), 853–858.
http://doi.org/10.1177/1087057109340314.A

Gozalbes, R., Mosulén, S., Carbajo, R. J., & Pineda-Lucena, A.
Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors. Journal of Computer-Aided Molecular Design, 2009, 23(8), 555–569.
http://doi.org/10.1007/s10822-009-9269-0

Haiech, J., Heizmann, C. W., & Krebs, J.
The 10th European symposium on calcium-binding proteins in normal and transformed cells. Biochimica et Biophysica Acta, 2009, 1793(6), 931–2.
http://doi.org/10.1016/j.bbamcr.2009.05.001

Haynes, M. K., Strouse, J. J., Waller, A., Leitao, A., Curpan, R. F., Bologa, C., Thompson, T. A.
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system. Journal of Biomolecular Screening, 2009, 14(6), 596–609.
http://doi.org/10.1177/1087057109335671

Hibert, M. F.
French/European academic compound library initiative. Drug Discovery Today, 2009, 14(15–16), 723–725.
http://doi.org/10.1016/j.drudis.2009.05.012

Huang, X., Setola, V., Yadav, P. N., Allen, J. a, Rogan, S. C., Hanson, B. J., Roth, B. L
Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine 2B Receptor Agonists : Implications for Drug Safety Assessment. Molecular Pharmacology, 2009, 5(4), 710–722.
http://doi.org/10.1124/mol.109.058057

Iorns, E., Lord, C. J., & Ashworth, A.
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. The Biochemical Journal, 2009, 417, 361–370.
http://doi.org/10.1042/BJ20081682

Kemmer, D., McHardy, L. M., Hoon, S., Rebérioux, D., Giaever, G., Nislow, C., Roberge, M.
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. BMC Microbiology, 2009, 9(1), 9.
http://doi.org/10.1186/1471-2180-9-9

Lagunin, A., Filimonov, D., Zakharov, A., Xie, W., Huang, Y., Zhu, F., Poroikov, V.
Computer-aided prediction of rodent carcinogenicity by PASS and CISOC-PSCT. QSAR and Combinatorial Science, 2009, 28(8), 806–810.
http://doi.org/10.1002/qsar.200860192

Langer, T., Hoffmann, R., Bryant, S., Lesur, B.
Hit finding: towards “smarter” approaches. Current Opinion in Pharmacology, 2009, 9(5), 589–593.
http://doi.org/10.1016/j.coph.2009.06.001

Larsen, R. S., Zylka, M. J., & Scott, J. E.
A high throughput assay to identify small molecule modulators of prostatic acid phosphatase. Current Chemical Genomics, 2009, 3, 42–9.
http://doi.org/10.2174/1875397300903010042

Livingstone, M., Larsson, O., Sukarieh, R., Pelletier, J., Sonenberg, N.
A Chemical Genetic Screen for mTOR Pathway Inhibitors Based on 4E-BP-Dependent Nuclear Accumulation of eIF4E. Chemistry and Biology, 2009, 16(12), 1240–1249.
http://doi.org/10.1016/j.chembiol.2009.11.010

MacArthur, R., Leister, W., Veith, H., Shinn, P., Southall, N., Austin, C. P., Auld, D. S.
Monitoring Compound Integrity with cytochrome P450 assays and qHTS. www.sbsonline.org, 2009, 1–9.
http://doi.org/10.1177/1087057109336954

Manuscript, A., & Formation, H. T. F. NIH Public Access, 2009, 358(1), 1–6.
http://doi.org/10.1016/j.bbrc.2007.03.056.High

Mulero, M. C., Aubareda, A., Orzáez, A., Messeguer, J., Serrano-Candelas, E., Martínez-Hoyer, S., Pérez-Riba, M.
Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. Journal of Biological Chemistry, 2009, 284(14), 9394–9401.
http://doi.org/10.1074/jbc.M805889200

Norton, J. T., Titus, S. A., Dexter, D., Austin, C. P., Zheng, W., Huang, S.
Automated high-content screening for compounds that disassemble the perinucleolar compartment. Journal of Biomolecular Screening, 2009, 14(9), 1045–1053.
http://doi.org/10.1177/1087057109343120
Orzáez, M., Mondragón, L., García-Jareño, A., Mosulén, S., Pineda-Lucena, A., Pérez-Payá, E. (2009).
Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL. Bioorganic and Medicinal Chemistry Letters, 2009, 19(6), 1592–1595.
http://doi.org/10.1016/j.bmcl.2009.02.020

Perne, A., Muellner, M. K., Steinrueck, M., Craig-Mueller, N., Mayerhofer, J., Schwarzinger, I., Mayerhofer, M.
Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis. PLOS ONE, 2009, 4(12).
http://doi.org/10.1371/journal.pone.0008292

Porotto, M., Orefice, G., Yokoyama, C. C., Mungall, B. A., Realubit, R., Sganga, M. L., Moscona, A.
Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. Journal of Virology, 2009, 83(10), 5148–5155.
http://doi.org/10.1128/JVI.00164-09

Pyeon, D., Pearce, S. M., Lank, S. M., Ahlquist, P., Lambert, P. F.
Establishment of human papillomavirus infection requires cell cycle progression. PLoS Pathogens, 2009, 5(2).
http://doi.org/10.1371/journal.ppat.1000318

Sanders, B. D., Jackson, B., Brent, M., Taylor, A. M., Dang, W., Berger, S. L., Marmorstein, R.
Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorganic and Medicinal Chemistry, 2009, 17(19), 7031–7041.
http://doi.org/10.1016/j.bmc.2009.07.073

Sung, J. C., Jensen, N. H., Kurome, T., Kadari, S., Manzano, M. L., Malberg, J. E., Kozikowski, A. P.
Selective 5-hydroxytryptamine 2c receptor agonists derived from the lead compound tranylcypromine: Identification of drugs with antidepressant-like action. Journal of Medicinal Chemistry, 2009, 52(7), 1885–1902.
http://doi.org/10.1021/jm801354e

Wible, B. A.
Incidence and specificity of drug-induced trafficking inhibition of cardiac ion channels. Journal of Pharmacological and Toxicological Methods, 2009, 60(2), 223.
http://doi.org/10.1016/j.vascn.2009.04.068

Zhu, P. J., Hobson, J. P., Southall, N., Qiu, C., Thomas, C. J., Lu, J., Liu, S.
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic and Medicinal Chemistry, 2009, 17(14), 5139–5145.
http://doi.org/10.1016/j.bmc.2009.05.054

Cascales, L., Mas-Moruno, C., Tamborero, S., Aceña, J. L., Sanz-Cervera, J. F., Fustero, S., Pérez-Payá, E.
Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-α production in the cell. Chemical Biology and Drug Design, 2008, 72(4), 320–328.
http://doi.org/10.1111/j.1747-0285.2008.00703.x

Desbordes, S. C., Placantonakis, D. G., Ciro, A., Socci, N. D., Lee, G., Djaballah, H., Studer, L.
High-Throughput Screening Assay for the Identification of Compounds Regulating Self-Renewal and Differentiation in Human Embryonic Stem Cells. Cell Stem Cell, 2008, 2(6), 602–612.
http://doi.org/10.1016/j.stem.2008.05.010

Garcia-Lopez, A., Monferrer, L., Garcia-Alcover, I., Vicente-Crespo, M., Alvarez-Abril, M. C., Artero, R. D.
Genetic and chemical modifiers of a CUG toxicity model in Drosophila. PLOS ONE, 2008, 3(2).
http://doi.org/10.1371/journal.pone.0001595

Hoffmann, H. H., Palese, P., Shaw, M. L.
Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity. Antiviral Research, 2008, 80(2), 124–134.
http://doi.org/10.1016/j.antiviral.2008.05.008

Hutchinson, D., Ho, V., Dodd, M., Dawson, H. N., Zumwalt, A. C., Colton, C. A.
NIH Public Access, 2008, 148(4), 825–832.
http://doi.org/10.1038/jid.2014.371

Ivnitski-Steele, I., Larson, R. S., Lovato, D. M., Khawaja, H. M., Winter, S. S., Oprea, T. I., Edwards, B. S.
High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters. Assay and Drug Development Technologies, 2008, 6(2), 263–276.
http://doi.org/10.1089/adt.2007.107

Johnson, R. L., Huang, W., Jadhav, A., Austin, C. P., Inglese, J., Martinez, E. D.
A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry, 2008, 375(2), 237–248.
http://doi.org/10.1016/j.ab.2007.12.028

Krysan, D. J., Didone, L.
A High-Throughput Screening Assay for Small Molecules, Journal of Biomolecular Screening, 2008, 13(7), 657–664.
http://doi.org/10.1177/1087057108320713

Lai, T. S., Liu, Y., Tucker, T., Daniel, K. R., Sane, D. C., Toone, E., Greenberg, C. S.
Identification of Chemical Inhibitors to Human Tissue Transglutaminase by Screening Existing Drug Libraries. Chemistry and Biology, 2008, 15(9), 969–978.
http://doi.org/10.1016/j.chembiol.2008.07.015

Mangat, C. S., Brown, E. D.
Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic Bacterial ATPase, YjeE. Chemistry and Biology, 2008, 15(12), 1287–1295.
http://doi.org/10.1016/j.chembiol.2008.10.007
Nakamura, K., Zawistowski, J. S., Hughes, M. a, Sexton, J. Z., Yeh, L.-A., Johnson, G. L., Scott, J. E.
Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization. Journal of Biomolecular Screening, 2008, 13(5), 396–405.
http://doi.org/10.1177/1087057108318281

Patnaik, D., Xian, J.
Molecule Inhibitors of the Mitotic Kinase Haspin By High-Throughput Screening Using a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer Assay. Journal of Biomolecular Screening, 2008, 13(10), 1025–1034.
http://doi.org/10.1177/1087057108326081.Identification

Senisterra, G. a, Soo Hong, B., Park, H.-W., Vedadi, M.
Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands. Journal of Biomolecular Screening, 2008, 13(5), 337–42.
http://doi.org/10.1177/1087057108317825

Seyb, K. I., Schuman, E. R., Ni, J., Huang, M., Michaelis, M. L., Glicksman, M. A.
Identification of Small Molecule Inhibitors of β–Amyloid Cytotoxicity through a Cell-based High-Throughput Screening Platform. Journal of Biomolecular Screening, 2008, 13(9), 870–878.
http://doi.org/10.1177/1087057108323909.Identification

Simeonov, A., Jadhav, A., Sayed, A. A., Wang, Y., Nelson, M. E., Thomas, C. J., Austin, C. P.
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Neglected Tropical Diseases, 2008, 2(1).
http://doi.org/10.1371/journal.pntd.0000127

Simeonov, A., Jadhav, A., Thomas, C. J., Wang, Y., Huang, R., Southall, N. T., Inglese, J.
Fluorescence spectroscopic profiling of compound libraries. Journal of Medicinal Chemistry, 2008, 51(8), 2363–2371.
http://doi.org/10.1021/jm701301m

Simeonov, A., Yasgar, A., Jadhav, A., Lokesh, G. L., Klumpp, C., Michael, S., Inglese, J.
Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Analytical Biochemistry, 2008, 375(1), 60–70.
http://doi.org/10.1016/j.ab.2007.11.039

Stoilov, P., Lin, C.-H., Damoiseaux, R., Nikolic, J., Black, D. L.
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators. Proceedings of the National Academy of Sciences, 2008, 105(32), 11218–11223.
http://doi.org/10.1073/pnas.0801661105

Tribouillard-Tanvier, D., Béringue, V., Desban, N., Gug, F., Bach, S., Voisset, C., Blondel, M.
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLOS ONE, 2008, 3(4).
http://doi.org/10.1371/journal.pone.0001981

Winter, S. S., Lovato, D. M., Khawaja, H. M., Edwards, B. S., Steele, I. D., Young, S. M., Larson, R. S.
High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent. Journal of Biomolecular Screening, 2008, 13(3), 185–93.
http://doi.org/10.1177/1087057108314610

Wu, Z., Liu, D., Sui, Y.
Quantitative assessment of hit detection and confirmation in single and duplicate high-throughput screenings. Journal of Biomolecular Screening, 2008, 13(2), 159–67.
http://doi.org/10.1177/1087057107312628

Xu, G. W., Mawji, I. A., Macrae, C. J., Koch, C. A., Datti, A., Wrana, J. L., Schimmer, A. D. A
High-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis, 2008, 13(3), 413–422.
http://doi.org/10.1007/s10495-007-0175-4

Antczak, C., Shum, D., Escobar, S., Bassit, B., Seshan, V. E., Wu, N., Djaballah, H.
High-Troughput Identification of Inhibitors of Human Mitochondrial Peptide Deformylase. J. Biomol. Screen, 2007, 12(4), 521–535.
http://doi.org/10.1177/1087057107300463

Azzaoui, K., Hamon, J., Faller, B., Whitebread, S., Jacoby, E., Bender, A., Urban, L.
Modeling promiscuity based on in vitro safety pharmacology profiling data. ChemMedChem, 2007, 2(6), 874–880.
http://doi.org/10.1002/cmdc.200700036

Bender, A., Scheiber, J., Glick, M., Davies, J. W., Azzaoui, K., Hamon, J., Jenkins, J. L.
Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. ChemMedChem, 2007, 2(6), 861–873.
http://doi.org/10.1002/cmdc.200700026

Breger, J., Fuchs, B. B., Aperis, G., Moy, T. I., Ausubel, F. M., Mylonakis, E.
Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathogens, 2007, 3(2), 0168–0178.
http://doi.org/10.1371/journal.ppat.0030018

Chong, C., Sullivan, D. J.
New uses for old drugs. Nature, 2007, 448(7154), 645.
http://dx.doi.org/10.1038/448645a\nhttp://www.nature(...)

Crisman, T. J., Parker, C. N., Jenkins, J. L., Scheiber, J., Thoma, M., Kang, Z. Bin, Glick, M.
Understanding false positives in reporter gene assays: In silico chemogenomics approaches to prioritize cell-based HTS data. Journal of Chemical Information and Modeling, 2007, 47(4), 1319–1327.
http://doi.org/10.1021/ci6005504
Crowe, A., Ballatore, C., Hyde, E., Trojanowski, J. Q., Lee, V. M.-Y.
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochemical and Biophysical Research Communications, 2007, 358(1), 1–6.
http://doi.org/10.1016/j.bbrc.2007.03.056

Davis, R. E., Zhang, Y.-Q., Southall, N., Staudt, L. M., Austin, C. P., Inglese, J., Auld, D. S. A
Cell-Based Assay for I κ B α Stabilization Using A Two-Color Dual Luciferase-Based Sensor. ASSAY and Drug Development Technologies, 2007, 5(1), 85–104.
http://doi.org/10.1089/adt.2006.048

Donahue, C. P., Ni, J., Rozners, E., Glicksman, M. a., Wolfe, M. S.
Identification of Tau Stem Loop RNA Stabilizers. Journal of Biomolecular Screening, 2007, 12(6), 789–799.
http://doi.org/10.1177/1087057107302676

Donahue, C. P., Ni, J., Rozners, E., Glicksman, M. a., Wolfe, M. S.
Identification of Tau Stem Loop RNA Stabilizers. Journal of Biomolecular Screening, 2007, 12(6), 789–799.
http://doi.org/10.1177/1087057107302676

Feng, B. Y., Simeonov, A., Jadhav, A., Babaoglu, K., Inglese, J., Shoichet, B. K., Austin, C. P. A
High-throughput screen for aggregation-based inhibition in a large compound library. Journal of Medicinal Chemistry, 2007, 50(10), 2385–2390.
http://doi.org/10.1021/jm061317y

Fischer, H., Kansy, M., Avdeef, A., & Senner, F.
Permeation of permanently positive charged molecules through artificial membranes-Influence of physico-chemical properties. European Journal of Pharmaceutical Sciences, 2007, 31(1), 32–42.
http://doi.org/10.1016/j.ejps.2007.02.001

Honson, N. S., Johnson, R. L., Huang, W., Inglese, J., Austin, C. P., Kuret, J.
Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiology of Disease, 2007, 28(3), 251–260.
http://doi.org/10.1016/j.nbd.2007.07.018

Hurtado-Guerrero, R., van Aalten, D. M. F.
Structure of Saccharomyces cerevisiae Chitinase 1 and Screening-Based Discovery of Potent Inhibitors. Chemistry and Biology, 2007, 14(5), 589–599.
http://doi.org/10.1016/j.chembiol.2007.03.015

Ivey, F. D., Wang, L., Demirbas, D., Allain, C., Hoffman, C. S.
Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases. Journal of Biomolecular Screening, 2007, 13(1), 62–71.
http://doi.org/10.1177/1087057107312127

Rezza, G., Nicoletti, L., Angelini, R., Romi, R., Finarelli, A., Panning, M., Cassone, A.
Infection with chikungunya virus in Italy: an outbreak in a temperate region. The Lancet, 2007, 370(9602), 1840–1846.
http://doi.org/10.1016/S0140-6736(07)61779-6

Sprous, D. G., Salemme, F. R.
A comparison of the chemical properties of drugs and FEMA/FDA notified GRAS chemical compounds used in the food industry. Food and Chemical Toxicology, 2007, 45(8), 1419–1427.
http://doi.org/10.1016/j.fct.2007.02.004

Tsetsarkin, K. A., Vanlandingham, D. L., Mcgee, C. E., Higgs, S.
A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential, PLOS Phatogens, 2007, 3(12).
http://doi.org/10.1371/journal.ppat.0030201

White, E. L., Southworth, K., Ross, L., Cooley, S., Gill, R. B., Sosa, M. I., Fletcher, T. M. A
Novel Inhibitor of Mycobacterium tuberculosis. Journal of Biomolecular Screening, 2007, 100–105.
http://doi.org/10.1177/1087057106296484

Bandyopadhyay, S.
A High-Throughput Drug Screen Targeted to the 5’Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA. Journal of Biomolecular Screening, 2007, 11(5), 469–480.
http://doi.org/10.1177/1087057106287271

Broom, W. J., Auwarter, K. E., Ni, J., Russel, D. E., Yeh, L.-A., Maxwell, M. M., Brown, R. H.
Two approaches to drug discovery in SOD1-mediated ALS. Journal of Biomolecular Screening, 2006, 11(7), 729–35.
http://doi.org/10.1177/1087057106290937

Dagher, R., Pigault, C., Bonnet, D., Boeglin, D., Pourbaix, C., Kilhoffer, M. C., Haiech, J.
Use of a fluorescent polarization based high throughput assay to identify new Calmodulin ligands. Biochimica et Biophysica Acta - Molecular Cell Research, 2006, 1763(11), 1250–1255.
http://doi.org/10.1016/j.bbamcr.2006.09.027

Fara, D. C., Oprea, T. I., Prossnitz, E. R., Bologa, C. G., Edwards, B. S., Sklar, L. A.
Integration of virtual and physical screening. Drug Discovery Today: Technologies, 2006, 3(4), 377–385.
http://doi.org/10.1016/j.ddtec.2006.11.003

Hergenrother, P. J.
Obtaining and screening compound collections: a user’s guide and a call to chemists. Current Opinion in Chemical Biology, 2006, 10(3), 213–218.
http://doi.org/10.1016/j.cbpa.2006.04.005

Inglese, J., Auld, D. S., Jadhav, A., Johnson, R. L., Simeonov, A., Yasgar, A., Austin, C. P.
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(7), 11473–11478.
http://doi.org/10.1073/pnas.0604348103

Kinobe, R. T., Dercho, R. a, Vlahakis, J. Z., Brien, J. F., Szarek, W. A, Nakatsu, K.
Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. The Journal of Pharmacology and Experimental Therapeutics, 2006, 319(1), 277–284.
http://doi.org/10.1124/jpet.106.102699.adjunctive

Monge, A., Arrault, A., Marot, C., Morin-Allory, L.
Managing, profiling and analyzing a library of 2.6 million compounds gathered from 32 chemical providers. Molecular Diversity, 2006, 10(3), 389–403.
http://doi.org/10.1007/s11030-006-9033-5
Ogawa, Y., Mizumoto, N., Tanaka, H., Matsushima, H., Takashima, A.
Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. J Invest Dermatol, 2006, 126(2), 349–353.
http://doi.org/10.1038/sj.jid.5700081

Peters, U., Cherian, J., Kim, J. H., Kwok, B. H., Kapoor, T. M.
Probing cell-division phenotype space and Polo-like kinase function using small molecules. Nature Chemical Biology, 2006, 2(11), 618–626.
http://doi.org/10.1038/nchembio826

Schuffenecker, I., Iteman, I., Michault, A., Murri, S., Frangeul, L., Vaney, M. C., Brisse, S.
Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Medicine, 2006, 3(7), 1058–1070.
http://doi.org/10.1371/journal.pmed.0030263

Severson, W. E., Shindo, N., Sosa, M., Fletcher, T., White, E. L., Ananthan, S., Jonsson, C. B.
Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its Application in Screening of a 100,000-Compound Library. Journal of Biomolecular Screening, 2006, 12(1), 33–40.
http://doi.org/10.1177/1087057106296688

Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M., Ferguson, M. A. J.
Identification of novel inhibitors of UDP-Glc 4’-epimerase, a validated drug target for african sleeping sickness. Bioorganic and Medicinal Chemistry Letters, 2006, 16(22), 5744–5747.
http://doi.org/10.1016/j.bmcl.2006.08.091

Wang, J. K. T., Portbury, S., Thomas, M. B., Barney, S., Ricca, D. J., Morris, D. L., Lo, D. C.
Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(27), 10461–6.
http://doi.org/10.1073/pnas.0600930103

Wu, X., Zhong, H., Song, J., Damoiseaux, R., Yang, Z., Lin, S.
Mycophenolic acid is a potent inhibitor of angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2006, 26(10), 2414–2416.
http://doi.org/10.1161/01.ATV.0000238361.07225.fc

Yip, K. W., Mao, X., Au, P. Y. B., Hedley, D. W., Chow, S., Dalili, S., Liu, F. F.
Benzethonium chloride: A novel anticancer agent identified by using a cell-based small-molecule screen. Clinical Cancer Research, 2006, 12(18), 5557–5569.
http://doi.org/10.1158/1078-0432.CCR-06-0536

Yip, K. W., Ito, E., Mao, X., Au, P. Y. B., Hedley, D. W., Mocanu, J. D., Liu, F.-F.
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Molecular Cancer Therapeutics, 2006, 5(9), 2234–40.
http://doi.org/10.1158/1535-7163.MCT-06-0134

Zotchev, S. B., Stepanchikova, A. V., Sergeyko, A. P., Sobolev, B. N., Filimonov, D. A., Poroikov, V. V.
Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases. Journal of Medicinal Chemistry, 2006, 49(6), 2077–2087.
http://doi.org/10.1021/jm051035i

Bakshi, P., Liao, Y.-F., Gao, J., Ni, J., Stein, R., Yeh, L.-A., Wolfe, M. S.
A High-Throughput Screen to Identify Inhibitors of Amyloid beta-Protein Precursor Processing. Journal of Biomolecular Screening, 2005, 10(1), 1–12.
http://doi.org/10.1177/1087057104270068

Case, A., Ni, J., Yeh, L. A., Stein, R. L.
Development of a mechanism-based assay for tissue transglutaminase - Results of a high-throughput screen and discovery of inhibitors. Analytical Biochemistry, 2005, 338(2), 237–244.
http://doi.org/10.1016/j.ab.2004.09.047

Edwards, B. S., Bologa, C., Young, S. M., Balakin, K. V, Prossnitz, E. R., Savchuck, N. P., Oprea, T. I.
Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide. Molecular Pharmacology, 2005, 68(5), 1301–1310.
http://doi.org/10.1124/mol.105.014068.phenylalanine

Mizumoto, N., Gao, J., Matsushima, H., Ogawa, Y., Tanak a, H., Takashima, A.
Discovery of novel immunostimulants by dendritic-cell – based functional screening. Blood, 2005, 106(9), 3082–3090.
http://doi.org/10.1182/blood-2005-03-1161

O’Connor, K. A., Roth, B. L.
Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery. Nat Rev Drug Discov, 2005, 4(12), 1005–1014.
http://doi.org/10.1038/nrd1900

Rao, F. V., Andersen, O. A., Vora, K. A., DeMartino, J. A., Van Aalten, D. M. F.
Methylxanthine drugs are chitinase inhibitors: Investigation of inhibition and binding modes. Chemistry and Biology, 2005, 12(9), 973–980.
http://doi.org/10.1016/j.chembiol.2005.07.009

Ray, S. S., Nowak, R. J., Brown, R. H., Lansbury, P. T.
Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(10), 3639–3644.
http://doi.org/10.1073/pnas.0408277102

Razonable, R. R., Henault, M., Watson, H. L., Paya, C. V.
Nystatin induces secretion of interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism. Antimicrobial Agents and Chemotherapy, 2005, 49(8), 3546–3549.
http://doi.org/10.1128/AAC.49.8.3546-3549.2005

Wible, B. A., Hawryluk, P., Ficker, E., Kuryshev, Y. A., Kirsch, G., Brown, A. M. HERG-Lite®:
A novel comprehensive high-throughput screen for drug-induced hERG risk. Journal of Pharmacological and Toxicological Methods, 2005, 52(1), 136–145.
http://doi.org/10.1016/j.vascn.2005.03.008



Young, S. M.
High-Throughput Screening with HyperCyt(R) Flow Cytometry to Detect Small Molecule Formylpeptide Receptor Ligands. Journal of Biomolecular Screening, 2005, 10(4), 374–382.
http://doi.org/10.1177/1087057105274532

Ahn, J. S.
Development of an Assay to Screen for Inhibitors of Tau Phosphorylation by Cdk5. Journal of Biomolecular Screening, 2004, 9(2), 122–131.
http://doi.org/10.1177/1087057103260594

Doan, T.
High-throughput target validation in model organisms. Drug Discovery Today: TARGETS, 2004, 3(5), 191–197.
http://doi.org/10.1016/S1741-8372(04)02452-1

Edwards, B. S., Oprea, T., Prossnitz, E. R., Sklar, L. A.
Flow cytometry for high-throughput, high-content screening. Current Opinion in Chemical Biology, 2004, 8(4), 392–398.
http://doi.org/10.1016/j.cbpa.2004.06.007

Gaud, A., Simon, J. M., Witzel, T., Carre-Pierrat, M., Wermuth, C. G., & Ségalat, L.
Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans. Neuromuscular Disorders, 2004, 14(6), 365–370.
http://doi.org/10.1016/j.nmd.2004.02.011

Wermuth, C. G.
Selective Optimization of Side Activities: Another Way for Drug Discovery. Journal of Medicinal Chemistry, 2004, 47(6), 1303–1314.
http://doi.org/10.1002/9781118098141.ch11

Rushton, D. N.
Functional Electrical Stimulation and rehabilitation—an hypothesis. Medical Engineering & Physics, 2003, 25, 75–78.
http://doi.org/10.1016/S

Oprea, T. I.
Virtual screening in lead discovery: A viewpoint. Molecules, 2002, 7(1), 51–62.
http://doi.org/10.3390/70100051

Poroikov, V. V., Filimonov, D. A.
How to acquire new biological activities in old compounds by computer prediction. Journal of Computer-Aided Molecular Design, 2002, 16(11), 819–824.
http://doi.org/10.1023/A:1023836829456112

40
PROJECTS

10 compounds
IN CLINICAL PHASE

1 COMPOUND
ON THE MARKET

650 Clients
FOR THE LIBRARIES