success-story

Home

Success Stories

Publications
Multi-omics “Upstream Analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer

EUPROT

Koschmann J, Poroikov V, Wingender KE
EUPROT (2016)

Publications
Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer’s disease

Alzheimer's and Dementia: Translational Research and Clinical Interventions

Koppel J, Jimenez H, Adrien L, Greenwald B, Marambaud P, Cinamon E, Davies P
Alzheimer's and Dementia: Translational Research and Clinical Interventions - vol. 2 121-130 (2016)

? 2016 The AuthorsIntroduction The use of antipsychotic medications in Alzheimer’s disease has been associated with an increased risk of mortality in clinical trials. However, an older postmortem literature suggests that those with schizophrenia treated in an era of exclusively conventional antipsychotic medications had a surprisingly low incidence of tau pathology. No previously published studies […]

Publications
Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples

Analytical and Bioanalytical Chemistry

Guetschow ED, Kumar S, Lombard DB, Kennedy RT
Analytical and Bioanalytical Chemistry - vol. 408 721-731 (2016)

Publications
Treatment of chronic enterovirus encephalitis with fluoxetine in a patient with X-linked agammaglobulinemia

Pediatric Neurology

Gofshteyn J, Cárdenas AM, Bearden D
Pediatric Neurology (2016)

Publications
RE(ACT) Congress. 9-12 March 2016, Barcelona. 3rd International Congress on Research of Rare and Orphan Diseases. 9th to 12th March 2016. Crowne Plaza Barcelona – Fira Center, Barcelona, Spain: Abstracts

Molecular Syndromology

Foundation S, Orphan ON, Suisse F, La P, Sur R, Maladies LES, Svizzera F, La PER, Sulle R, Orfane M
Molecular Syndromology - vol. 6 304-335 (2016)

Publications
High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

Disease Models & Mechanisms

Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJV, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R
Disease Models & Mechanisms - vol. 9 685-696 (2016)

Publications
Fragment pharmacophore-based in silico screening: A powerful approach for efficient lead discovery

Med. Chem. Commun.

Deyon-Jung L, Morice C, Chéry F, Gay J, Langer T, Frantz M, Rozot R, Dalko-Csibe M
Med. Chem. Commun. - vol. 7 506-511 (2016)

Publications
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine ␤ -synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon

Pharmacological Research

Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-garcía I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C
Pharmacological Research - vol. 113 18-37 (2016)

Publications
Characterization and application of two RANK-specific antibodies with different biological activities

Immunology Letters

Chypre M, Seaman J, Cordeiro OG, Willen L, Knoop KA, Buchanan A, Sainson RCA, Williams IR, Yagita H, Schneider P, Mueller CG
Immunology Letters - vol. 171 5-14 (2016)

Antibodies play an important role in therapy and investigative biomedical research. The TNF-family member Receptor Activator of NF-??B (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. However, the study of RANK biology has been hampered by missing or insufficient […]

Publications
Identifying ligands at orphan GPCRs : current status using structure-based approaches Tables of Links

British Journal of Pharmacology

Ngo T, Kufareva I, Coleman JLJ, Graham RM, Abagyan R, Smith NJ
British Journal of Pharmacology - vol. 173 2934-2951 (2016)