Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation.

The open microbiology journal
Il y a 13 années

Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered exploration for novel and unconventional approaches to controlling microbial infections. Multidrug efflux systems (MES) have been a profound obstacle in the successful deployment of antimicrobials. The discovery of small molecule efflux system blockers […]

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