Orthologue selectivity and ligand bias: Translating the pharmacology of GPR35

Trends in Pharmacological Sciences
Il y a 15 années

GPR35 is a poorly characterized G protein-coupled receptor (GPCR) that has been suggested as a potential therapeutic target for the treatment of diabetes, hypertension and asthma. Two endogenously produced ligands have been suggested as activators of GPR35, although the relevance of these remains unclear. Recently, a series of surrogate agonist ligands and the first antagonists […]

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