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Success Stories


Publications
Use of cell-based screening to identify small-molecule compounds that modulate claudin-4 expression

Biotechnology Letters

Watari A, Hashegawa M, Muangman T, Yagi K, Kondoh M
Biotechnology Letters - vol. 37 1177-1185 (2015)

Claudins constitute a family of at least 27 proteins with four transmembrane domains, and play a pivotal role in maintaining tight-junctions seals in diverse epithelial tissues. The expression of claudin-4 often changes in intestinal tissues of inflammatory bowel disease and various human cancers. Therefore, claudin-4 is a promising target for treatment of these diseases. In […]

Publications
Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans

Journal of Biomolecular Screening

Preuett B, Leeder JS, Abdel-Rahman S
Journal of Biomolecular Screening - vol. 20 1171-1177 (2015)

Publications
Glucocorticoids Suppress Renal Cell Carcinoma Progression by Enhancing Na,K-ATPase Beta-1 Subunit Expression

Plos One

Huynh TP, Barwe SP, Lee SJ, McSpadden R, Franco OE, Hayward SW, Damoiseaux R, Grubbs SS, Petrelli NJ, Rajasekaran AK
Plos One - vol. 10 e0122442 (2015)

Publications
Cell-based Screening Identifies a Rosette-Disrupting Antimalarial for the Treatment of Plasmodium falciparum Malaria Complications

Blood

Ch’ng J, Moll K, Quintana MDP, Chan S, Moles E, Liu J, Eriksson AB, Wahlgren M
Blood 1-13 (2015)

Publications
DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER

Oncogene

Bharadwaj U. ET, Mancini ADJT
Oncogene - vol. 34 1341-1353 (2015)

Signal transducer and activator of transcription (STAT) 3 regulates many cardinal features of cancer including cancer cell growth, apoptosis resistance, DNA damage response, metastasis, immune escape, tumor angiogenesis, the Warburg effect, and oncogene addiction and has been validated as a drug target for cancer therapy. Several strategies have been employed to identify agents that target […]

Publications
Cancer stem cell quiescence and plasticity as major challenges in cancer therapy

Stem Cells International

Chen W, Dong J, Haiech J, Kilhoffer MC, Zeniou M
Stem Cells International - vol. 2016 (2016)

Cells with stem-like properties, tumorigenic potential, and treatment-resistant phenotypes have been identified in many human malignancies. Based on the properties they share with nonneoplastic stem cells or their ability to initiate and propagate tumors in vivo, such cells were designated as cancer stem (stem-like) or tumor initiating/propagating cells. Owing to their implication in treatment resistance, […]

Publications
Screening a Commercial Library of Pharmacologically Active Small Molecules Against Staphylococcus aureus Biofilms

Antimicrobial Agents and Chemotherapy

Torres NS, Abercrombie JJ, Srinivasan A, Lopez-Ribot JL, Ramasubramanian AK, Leung KP
Antimicrobial Agents and Chemotherapy AAC.00377-16 (2016)

It is now well established that bacterial infections are often associated with biofilm phenotypes that demonstrate increased resistance to common antimicrobials. Further, due to the collective attrition of new-antibiotic development programs by the pharmaceutical industries, drug repurposing is an attractive alternative. In this work, we have screened 1,280 existing commercially available drugs in the Prestwick […]

Publications
Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass

Stem Cell Reports

Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, Kume S
Stem Cell Reports - vol. 7 95-109 (2016)

Publications
Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells

Free Radical Biology and Medicine

Timiri Shanmugam PS, Nair RP, De Benedetti A, Caldito G, Abreo F, Sunavala-Dossabhoy G
Free Radical Biology and Medicine - vol. 93 217-226 (2016)

Accidental or medical radiation exposure of the salivary glands can gravely impact oral health. Previous studies have shown the importance of Tousled-like kinase 1 (TLK1) and its alternate start variant TLK1B in cell survival against genotoxic stresses. Through a high-throughput library screening of natural compounds, the phenolic phytochemical, gallic acid (GA), was identified as a […]

Publications
Identification of novel molecules targeting cartilage aging as osteoarthritis therapeutics

Osteoarthritis and Cartilage

Nogueira U, Dominguez E, Loza M, Blanco F, Carames B
Osteoarthritis and Cartilage - vol. 24 S18-S19 (2016)