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Success Stories


Publications
Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide

Molecular pharmacology

Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI
Molecular pharmacology - vol. 68 1301-1310 (2005)

Publications
Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its Application in Screening of a 100,000-Compound Library

Journal of Biomolecular Screening

Severson WE, Shindo N, Sosa M, Fletcher T, White EL, Ananthan S, Jonsson CB
Journal of Biomolecular Screening - vol. 12 33-40 (2006)

Publications
Foreword

Journal of Physiology-Paris

Shimahara T
Journal of Physiology-Paris - vol. 99 73-74 (2006)

Publications
Integration of virtual and physical screening

Drug Discovery Today: Technologies

Fara DC, Oprea TI, Prossnitz ER, Bologa CG, Edwards BS, Sklar LA
Drug Discovery Today: Technologies - vol. 3 377-385 (2006)

High-throughput screening (HTS) represents the dominant technique for the identification of new lead compounds in current drug discovery. It consists of physical screening (PS) of large libraries of chemicals against one or more specific biological targets. Virtual screening (VS) is a strategy for in silico evaluation of chemical libraries for a given target, and can […]

Publications
A High-Throughput Drug Screen Targeted to the 5’Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA

Journal of Biomolecular Screening

Bandyopadhyay S
Journal of Biomolecular Screening - vol. 11 469-480 (2006)

Publications
A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential

Tsetsarkin KA, Vanlandingham DL, Mcgee CE, Higgs S
- vol. 3 (2007)

Publications
Infection with chikungunya virus in Italy: an outbreak in a temperate region

The Lancet

Rezza G, Nicoletti L, Angelini R, Romi R, Finarelli A, Panning M, Cordioli P, Fortuna C, Boros S, Magurano F, Silvi G, Angelini P, Dottori M, Ciufolini M, Majori G, Cassone A
The Lancet - vol. 370 1840-1846 (2007)

BACKGROUND Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy. METHODS After reports of a large number of cases of febrile illness of unknown origin in two contiguous villages in northeastern […]

Publications
A Novel Inhibitor of Mycobacterium tuberculosis

Journal of Biomolecular Screening

White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM
Journal of Biomolecular Screening 100-105 (2007)

Publications
Drug Repurposing

MSI Consultancy

Stuart-Kregor P
MSI Consultancy (2007)

Publications
Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases

Journal of Biomolecular Screening

Ivey FD, Wang L, Demirbas D, Allain C, Hoffman CS
Journal of Biomolecular Screening - vol. 13 62-71 (2007)