Case Studies

Case Studies
A high-throughput differential chemical genetic screen uncovers genotype-specific compounds altering plant growth
The identification of chemical compounds regulating plant growth in a genetic context can greatly enhance our understanding of biological mechanisms.

 Côme Emmenecker, Jingqi Dai, Sandrine Lefranc, Ayoub Ouddah, Julie Guerin, Simine Pakzad, Philippe Andreyand Rajeev Kumar1
 iScience 112375 (2025)

The identification of chemical compounds regulating plant growth in a genetic context can greatly enhance our understanding of biological mechanisms. Here, we have developed a high-throughput phenotypedirected chemical screening method in plants to compare two genotypes and identify small molecules inducing genotype-specific phenotypes. We used Arabidopsis thaliana wild type and mus81, a DNA repair mutant, […]

Case Studies
Drug Repositioning as a Therapeutic Strategy against Streptococcus pneumoniae: Cell Membrane as Potential Target

 Laura Ortiz-Miravalles, Manuel Sánchez-Angulo, Jesús M Sanz , Beatriz Maestro
 Int. J. Mol. Sci. 5831 (2023)

A collection of repurposing drugs (Prestwick Chemical Library) containing 1200 compounds was screened to investigate the drugs’ antimicrobial effects against planktonic cultures of the respiratory pathogen Streptococcus pneumoniae. After four discrimination rounds, a set of seven compounds was finally selected, namely (i) clofilium tosylate; (ii) vanoxerine; (iii) mitoxantrone dihydrochloride; (iv) amiodarone hydrochloride; (v) tamoxifen citrate; […]

Case Studies
Use of the Prestwick Chemical Drug-Library for COVID research
In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication.

 F. Touret, M. Gilles, K. Barral, A. Nougairède, E. Decroly, X. de Lamballerie & B. Coutard
 bioRxiv (2020)

Repurposing of approved drugs is a strategy that can bypass the time-consuming stages of drug development. In this study, the researchers screened the PRESTWICK CHEMICAL LIBRARY composed of 1,520 approved drugs in an infected cell-based assay. The robustness of the screen was assessed by the identification of drugs that already demonstrated in vitro antiviral effect […]

Case Studies
Drug repurposing: a compound from the Prestwick Chemical Library Riboflavin Completed Phase 2 Trials for Stroke, Ischemic Treatment
Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke.

 A. da Silva-Candal, A. Pérez-Diaz, M. Santamaria, C. Correa-Paz, M. Rodriguez-Yanez, A. Arda, M. Perez-Mato, R. Iglesias-Rey, J. Brea, J. Azuaje, E. Sotelo, T. Sobrino, MI Loza, J. Castillo & F. Campos.
 Ann. Neurol. 84 260–273 (2018)

Blood/brain-glutamate grabbing is an emerging concept in the treatment of ischemic stroke, where essentially the deleterious effects of glutamate after ischemia are ameliorated by coaxing glutamate to enter the bloodstream and thus reducing its concentration in the brain. The authors aim to demonstrate the clinical efficacy of blood glutamate grabbers in patients with stroke, and […]

All our screening libraries

Partners