Publications

Publications
HERG-Lite??: A novel comprehensive high-throughput screen for drug-induced hERG risk
Journal of Pharmacological and Toxicological Methods

 Wible BA, Hawryluk P, Ficker E, Kuryshev YA, Kirsch G, Brown AM
 Journal of Pharmacological and Toxicological Methods - vol. 52 136-145 (2005)

Introduction: Direct block of IKr by non-antiarrhythmic drugs (NARDs) is a major cause of QT prolongation and torsades de pointes (TdP), and has made the hERG potassium channel a major target of drug safety programs in cardiotoxicity. Block of hERG currents is not the only way that drugs can adversely impact the repolarizing current IKr, […]

Publications
Development of a mechanism-based assay for tissue transglutaminase – Results of a high-throughput screen and discovery of inhibitors
Analytical Biochemistry

 Case A, Ni J, Yeh LA, Stein RL
 Analytical Biochemistry - vol. 338 237-244 (2005)

Tissue transglutaminase (TGase) is a Ca2+-dependent enzyme that catalyzes cross-linking of intracellular proteins through a mechanism that involves isopeptide bond formation between Gln and Lys residues. In addition to its transamidation activity, TGase can bind guanosine 5???-triphosphate (GTP) and does so in a manner that is antagonized by calcium. Once bound, GTP undergoes hydrolysis to […]

Publications
Multi-parameter high throughput screening assays (MPHTS)
Society

 Altar CA, Brockman JA, Evans D, Hook DJ, Klimczak LJ, Laeng P, Palfreyman M, Rajan P
 Society - vol. 9 51 (2005)

The present invention relates to screening methods and assays that are referred to herein as multi-parameter hight throughput screening (MPHTS) assays. These MPHTS assays are useful for identifying candidate pharmaceutical compounds. In particular, the screening methods of this invention may be used to identify compounds that have potential therapeutic bene?ts for the treatment of neurop […]

Publications
( 19 ) United States ( 12 ) Patent Application Publication ( 10 ) Pub . No .: US 2010 / 0041620 A1 Publication Classi ? cation 6 Weak Followup Patent Application Publication

 Ruebel S, Stuemke M
  - vol. 1 11 (2004)

The invention relates to a bath for the electrodeposition of gold and gold alloys and to its use for producing dental moldings. In this bath, the gold is in the form of a gold sul?te complex. The bath according to the invention and/or the use according to the invention is distinguished by the fact that […]

Publications
Flow cytometry for high-throughput, high-content screening
Current Opinion in Chemical Biology

 Edwards BS, Oprea T, Prossnitz ER, Sklar LA
 Current Opinion in Chemical Biology - vol. 8 392-398 (2004)

Flow cytometry is a mature platform for quantitative multi-parameter measurement of cell fluorescence. Recent innovations allow up to 30-fold faster serial processing of bulk cell samples. Homogeneous discrimination of free and cell-bound fluorescent probe eliminates wash steps to streamline sample processing. Compound screening throughput may be further enhanced by multiplexing of assays on color-coded bead […]

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