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Prestwick Chemical Library^®

The Prestwick Chemical Library^® contains 1200 small molecules, 100% being marketed drugs, thus it presents the greatest possible degree of drug-likeliness. The active compounds were selected for their high chemical and pharmacological diversity as well as for their known bioavailability and safety in humans. The Prestwick Chemical Library ® was designed to reduce the risk of "low quality" hits, reduce the cost of the initial screening, and accelerate lead discovery.

What's the ideal use of the library ?

The strategy we recommend is the "SOSA Approach" (C.G. Wermuth, J. Med. Chem. 2004, 47, 1303-1314). It consists of submitting to the target only a limited number of highly diverse drug molecules for which bioavailability and toxicity studies have already been performed and which have proven usefulness in humans. This initial screening will provide hits that will then be used as starting points for a drug optimization program which will rely on medicinal chemistry expertise. It can be noticed that, if the initial hit has sufficient affinity for the target, it could be immediately tested in patients.

How provided ?

The Prestwick Chemical Library^® comes in two different presentations, either in DMSO solution and therefore ready for screening or in powder form. In the first one, compounds are supplied at precise 5 or 10 mM in DMSO and at various volumes between 200µL to 1 mL. In the second packaging, compounds come as dry powder and are supplied in vials, each one containing 10 - 100 mg of substance.

A database ready for use

The Prestwick Chemical Library^® is provided with a standard data file (SDF) containing more than 50 fields in a hierarchical structure that can be individually customized (some data are pre-registered). A database in DB as well as in XLS format is offered as well. Therefore, each library is supplied with a CD-ROM containing structures, chemical names and smiles of the compounds of the library, as well as useful physicochemical and biological data, literature references and precautions.

Additional amounts of substances

For all the active substances of the Prestwick Chemical Library^®, additional amounts up to 100mg can be provided at cost.

The Library is sold with "no strings attached" (i.e. no royalties or milestones are requested).