Disorders of the central nervous system (CNS) continue to be among the most alarming and devastating diseases of the 21th century. Unfortunately, the complexity of CNS diseases, the challenge of central drug delivery in combination with the high attrition rate of candidate therapeutics during development and clinical testing make CNS drug approval more difficult compared to other therapeutic areas.
However, there is a wide consensus that new and/or better treatments are urgently needed. And one of the key success factor from the long road from hit to pre-clinical candidate is the relevance of the initial screening library. In this way, to help you identify high quality hits, we propose you a unique collection of 320 structurally diverse approved and marketed drugs carefully selected by a pharmacist-chemist team for their pharmacological effects on the central nervous system.
With high degree of diversity in terms of therapeutic and biological targets, the Prestwick CNS drug library is ideally suited for high-throughput screening (HTS), high-content screening (HCS) as well as assay validation with the insurance that the molecule enters the brain.
The CNS MPO (Central Nervous System Multiparameter Optimization) function may be used to identify and select compounds with increased probability of success for CNS indications. The CNS MPO algorithm is a multi-parameter scoring profile based on 6 physicochemical properties: ClogP, ClogD, MW, TPSA, HBD, and pKa. MPO scores were calculated for the Prestwick CNS Drug Library and showed that more than 88% of the compounds have a MPO score above 4, which is in agreement with therapeutic indications and clinical observations.
|Pre-dissolved in DMSO ready for screening at precise 10 mM concentration and tailored volumes (100 µL to 1 mL) in 96 or 384 well plates, and customizable (volumes, plating)|
|As dry powder in vials starting at 10 mg, with cherry-picking possibility|
|Always provided with a highly annotated database as structural data file (SDF), IsisBase (DB) as well as an XLS file. Annotation includes target, therapeutic class/effect, side effects, patent and AMDET information|
|A file containing names and structures may be required on request prior purchasing|
|Additional amounts of substances:Re-supply of any hit-compound up to 100 mg provided at a small fee|