Screening for New Inhibitors of the Human Mitochondrial Pyruvate Carrier and Their Effects on Hepatic Glucose Production and Diabetes

Herzig, S.; Li, L.; Jiménez-Sánchez, C.; Martinou, J.-C.; Maechler, P.
Biochim Biophys Acta Gen Subj 130492 (2023)

The mitochondrial pyruvate carrier (MPC) is a protein complex composed of two subunits, MPC1 and MPC2

This carrier is at the interface between glycolysis and mitochondrial metabolism and plays an essential role in hepatic glucose production.

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