Archives des Latest Publications - Prestwick Chemical Libraries

Latest Publications


Latest Publications
A high-throughput differential chemical genetic screen uncovers genotype-specific compounds altering plant growth

The identification of chemical compounds regulating plant growth in a genetic context can greatly enhance our understanding of biological mechanisms.
Il y a 3 mois

The identification of chemical compounds regulating plant growth in a genetic context can greatly enhance our understanding of biological mechanisms. Here, we have developed a high-throughput phenotypedirected chemical screening method in plants to compare two genotypes and identify small molecules inducing genotype-specific phenotypes. We used Arabidopsis thaliana wild type and mus81, a DNA repair mutant, […]

Case studies
A high-throughput differential chemical genetic screen uncovers genotype-specific compounds altering plant growth

The identification of chemical compounds regulating plant growth in a genetic context can greatly enhance our understanding of biological mechanisms.

Côme Emmenecker, Jingqi Dai, Sandrine Lefranc, Ayoub Ouddah, Julie Guerin, Simine Pakzad, Philippe Andreyand Rajeev Kumar1
iScience 112375 (2025)

The identification of chemical compounds regulating plant growth in a genetic context can greatly enhance our understanding of biological mechanisms. Here, we have developed a high-throughput phenotypedirected chemical screening method in plants to compare two genotypes and identify small molecules inducing genotype-specific phenotypes. We used Arabidopsis thaliana wild type and mus81, a DNA repair mutant, […]