Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T
Molecular Neurodegeneration - vol. 11 46 (2016)
Kang J, Hsu C, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF
Nat Biotech - vol. 34 70-77 (2016)
High-content, image-based screens enable the identification of compounds that induce cellular responses similar to those of known drugs but through different chemical structures or targets. A central challenge in designing phenotypic screens is choosing suitable imaging biomarkers. Here we present a method for systematically identifying optimal reporter cell lines for annotating compound libraries (ORACLs), whose […]
Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K
Biochemical and Biophysical Research Communications - vol. 470 356-361 (2016)
Endochondral ossification is an essential process for reparative phase of fracture healing, which starts with the differentiation of mesenchymal cells into chondrocytes followed by substitution of bone tissue. It is strictly controlled by the expression of crucial transcriptional factors: SOX9 in the early phase and RUNX2 in the late phase. Screening of FDA-approved compounds revealed […]
Arvidsson PI, Sandberg K, Forsberg-Nilsson K
Drug Discovery Today - vol. 00 1-9 (2016)
Chen G, Masuda A, Konishi H, Ohkawara B, Ito M, Kinoshita M, Kiyama H, Matsuura T, Ohno K
Scientific reports - vol. 6 25317 (2016)
Myotonic dystrophy type 1 (DM1) is caused by abnormal expansion of CTG repeats in the 3′ untranslated region of the DMPK gene. Expanded CTG repeats are transcribed into RNA and make an aggregate with a splicing regulator, MBNL1, in the nucleus, which is called the nuclear foci. The nuclear foci sequestrates and downregulates availability of […]
Bastin J, Djouadi F
Nutrients - vol. 8 254 (2016)
Resveratrol is a natural polyphenolic compound produced by plants under various stress conditions. Resveratrol has been reported to exhibit antioxidant, anti-inflammatory, and anti-proliferative properties in mammalian cells and animal models, and might therefore exert pleiotropic beneficial effects in different pathophysiological states. More recently, resveratrol has also been shown to potentially target many mitochondrial metabolic pathways, […]
Coleman DT, Gray AL, Stephens CA, Scott ML, Cardelli JA
Oncotarget - vol. 7 1-10 (2016)
Ekins S, Mietchen D, Coffee M, Stratton T, Freundlich J, Freitas-Junior L, Muratov E, Siqueira-Neto J, Williams A, Andrade C
F1000Research - vol. 5 150 (2016)
The Zika virus (ZIKV) outbreak in the Americas has caused global concern that we may be on the brink of a healthcare crisis. The lack of research on ZIKV in the over 60 years that we have known about it has left us with little in the way of starting points for drug discovery. Our […]
Cordeiro OG, Chypre M, Brouard N, Rauber S, Alloush F, Romera-Hernandez M, B??n??zech C, Li Z, Eckly A, Coles MC, Rot A, Yagita H, L??on C, Ludewig B, Cupedo T, Lanza F, Mueller CG
PLoS ONE - vol. 11 1-16 (2016)
Cheng H, Chen T, Tor M, Park D, Zhou Q, Huang JB, Khatib N, Rong L, Zhou G
Journal of Biomolecular Screening - vol. 21 333-341 (2016)
Pulmonary arterial hypertension is a complex disease with multiple etiologic factors. PDLIM5, a member of the Enigma subfamily of PDZ and LIM domain protein family, contains an N-terminal PDZ domain and three LIM domains at its C-terminus. We have previously shown that overexpression of PDLIM5 prevents hypoxia-induced pulmonary hypertension (PH), and deletion of PDLIM5 in […]
