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Publications

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke

Annals of Neurology

da Silva-Candal A, Pérez-Díaz A, Santamaría M, Correa-Paz C, Rodríguez-Yáñez M, Ardá A, Pérez-Mato M, Iglesias-Rey R, Brea J, Azuaje J, Sotelo E, Sobrino T, Loza MI, Castillo J, Campos F
Annals of Neurology - vol. 84 260-273 (2018)

Objective: Blood/brain-glutamate grabbing is an emerging concept in the treatment of acute ischemic stroke, where essentially the deleterious effects of glutamate after ischemia are ameliorated by coaxing glutamate to enter the bloodstream and thus reducing its concentration in the brain. Aiming to demonstrate the clinical efficacy of blood glutamate grabbers in patients with stroke, in […]

Publications

Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation

Journal of Clinical Investigation

Hall CJ, Sanderson LE, Lawrence LM, Pool B, Van Der Kroef M, Ashimbayeva E, Britto D, Harper JL, Lieschke GJ, Astin JW, Crosier KE, Dalbeth N, Crosier PS
Journal of Clinical Investigation - vol. 128 1752-1771 (2018)

Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging […]

Publications

Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development

Antimicrob. Agents Chemother

Gina Wall AKC
Antimicrob. Agents Chemother (2018)

Publications

Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosoph ila cardiac model of Friedreich ’ s Keywords : Summary statement : Abstract :

Dis Model Mech.

Palandri A, Martin E, Russi M, Rera M
Dis Model Mech. - vol. 11 1-22 (2018)

Publications

SynAggreg : A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds

J Mol Biol

Aviolat H, Nominé Y, Gioria S, Bonhoure A
J Mol Biol - vol. 430 5257-5279 (2018)

Publications

Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

Disease Models & Mechanisms

Chakraborty M, Sellier C, Ney M, Pascal V, Charlet-berguerand N
Disease Models & Mechanisms - vol. 1 1-12 (2018)

Publications

A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry

SLAS Discovery

Tione Buranda CG
SLAS Discovery 1 (2018)

Publications

Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter a-b

Cell Mol Gastroenterol Hepatol

Sandra M. W. van de Wiel DRDW
Cell Mol Gastroenterol Hepatol - vol. 5 223-237 (2018)

Publications

Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens

mspher

Mamouei Z, Alqarihi A, Singh S, Xu S, Mansour MK, Ibrahim AS
mspher - vol. 3 1-11 (2018)

Publications

Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice

Diabetes Obes Metab.

Jung H, Park S, Hee S, Lee D, Lee I, Kim M, Jeong Y, Hee Y, Bs L
Diabetes Obes Metab. 1-14 (2018)

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