Extensive impact of non-antibiotic drugs on human gut bacteria


Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H, Patil KR, Bork P, Typas A
Nature - vol. 555 623-628 (2018)

A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Here, we screened more than 1,000 marketed drugs against 40 representative gut bacterial strains, and found that 24% of the drugs with human targets, including members of all therapeutic classes, inhibited […]

Screening for biologically annotated drugs that trigger triacylglycerol accumulation in the diatom Phaeodactylum

Plant Physiology

Melissa Conte JL
Plant Physiology 532-552 (2018)

Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions

Bioorganic and Medicinal Chemistry Letters

Ren J, Dsouza NR, Deng H, Lee H, Bouvier M, Johnson ME
Bioorganic and Medicinal Chemistry Letters - vol. 28 2837-2841 (2018)

The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an important role in Ad infections, which is the causative agent of a series of gastrointestinal, respiratory and ocular diseases. The objective of this research is to evaluate the essential interactions between E3-19K and HLA-A2 using the X-ray crystal structure […]

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke

Annals of Neurology

da Silva-Candal A, Pérez-Díaz A, Santamaría M, Correa-Paz C, Rodríguez-Yáñez M, Ardá A, Pérez-Mato M, Iglesias-Rey R, Brea J, Azuaje J, Sotelo E, Sobrino T, Loza MI, Castillo J, Campos F
Annals of Neurology - vol. 84 260-273 (2018)

Objective: Blood/brain-glutamate grabbing is an emerging concept in the treatment of acute ischemic stroke, where essentially the deleterious effects of glutamate after ischemia are ameliorated by coaxing glutamate to enter the bloodstream and thus reducing its concentration in the brain. Aiming to demonstrate the clinical efficacy of blood glutamate grabbers in patients with stroke, in […]

Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation

Journal of Clinical Investigation

Hall CJ, Sanderson LE, Lawrence LM, Pool B, Van Der Kroef M, Ashimbayeva E, Britto D, Harper JL, Lieschke GJ, Astin JW, Crosier KE, Dalbeth N, Crosier PS
Journal of Clinical Investigation - vol. 128 1752-1771 (2018)

Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging […]

Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development

Antimicrob. Agents Chemother

Gina Wall AKC
Antimicrob. Agents Chemother (2018)

Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosoph ila cardiac model of Friedreich ’ s Keywords : Summary statement : Abstract :

Dis Model Mech.

Palandri A, Martin E, Russi M, Rera M
Dis Model Mech. - vol. 11 1-22 (2018)

SynAggreg : A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds

J Mol Biol

Aviolat H, Nominé Y, Gioria S, Bonhoure A
J Mol Biol - vol. 430 5257-5279 (2018)

Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

Disease Models & Mechanisms

Chakraborty M, Sellier C, Ney M, Pascal V, Charlet-berguerand N
Disease Models & Mechanisms - vol. 1 1-12 (2018)

A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry

SLAS Discovery

Tione Buranda CG
SLAS Discovery 1 (2018)