Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA E ffl ux Pump Inhibitors

J. Med. Chem.

Astolfi A, Felicetti T, Iraci N, Manfroni G, Massari S, Pietrella D, Tabarrini O, Kaatz GW, Barreca ML, Sabatini S, Cecchetti V
J. Med. Chem. - vol. 60 1598-1604 (2017)

Toward the identi fi cation of viral cap-methyltransferase inhibitors by fl uorescence screening assay

Antiviral Research

Aouadi W, C E, Coutard B, Martin B, Aouadi W, Debart F, Jacques J, Marie J, Morice C, Jung M, Canard B, Guillemot J, Decroly E
Antiviral Research - vol. 144 330-339 (2017)

Applications of chemogenomic library screening in drug discovery

Nature Publishing Group

Jones LH, Bunnage ME
Nature Publishing Group - vol. 16 285-296 (2017)

Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins

ACS Chem. Biol.

Jones CL, Njomen E, Dexheimer TS, Tepe JJ
ACS Chem. Biol. - vol. 12 2240−2247 (2017)

High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors Report High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdo

C Chauvin AL, Delattre O, Nery ED, Leruste A, Tauziede-espariat A, Andrianteranagna M, Surdez D

Open for collaboration: an academic platform for drug discovery and development at SciLifeLab

Drug Discovery Today

Arvidsson PI, Sandberg K, Forsberg-Nilsson K
Drug Discovery Today - vol. 00 1-9 (2016)

Screening a Commercial Library of Pharmacologically Active Small Molecules Against Staphylococcus aureus Biofilms

Antimicrobial Agents and Chemotherapy

Torres NS, Abercrombie JJ, Srinivasan A, Lopez-Ribot JL, Ramasubramanian AK, Leung KP
Antimicrobial Agents and Chemotherapy AAC.00377-16 (2016)

It is now well established that bacterial infections are often associated with biofilm phenotypes that demonstrate increased resistance to common antimicrobials. Further, due to the collective attrition of new-antibiotic development programs by the pharmaceutical industries, drug repurposing is an attractive alternative. In this work, we have screened 1,280 existing commercially available drugs in the Prestwick […]

Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy.

Scientific reports

Chen G, Masuda A, Konishi H, Ohkawara B, Ito M, Kinoshita M, Kiyama H, Matsuura T, Ohno K
Scientific reports - vol. 6 25317 (2016)

Myotonic dystrophy type 1 (DM1) is caused by abnormal expansion of CTG repeats in the 3′ untranslated region of the DMPK gene. Expanded CTG repeats are transcribed into RNA and make an aggregate with a splicing regulator, MBNL1, in the nucleus, which is called the nuclear foci. The nuclear foci sequestrates and downregulates availability of […]

Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass

Stem Cell Reports

Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, Kume S
Stem Cell Reports - vol. 7 95-109 (2016)

Resveratrol and Myopathy


Bastin J, Djouadi F
Nutrients - vol. 8 254 (2016)

Resveratrol is a natural polyphenolic compound produced by plants under various stress conditions. Resveratrol has been reported to exhibit antioxidant, anti-inflammatory, and anti-proliferative properties in mammalian cells and animal models, and might therefore exert pleiotropic beneficial effects in different pathophysiological states. More recently, resveratrol has also been shown to potentially target many mitochondrial metabolic pathways, […]