Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation

Journal of Clinical Investigation

Hall CJ, Sanderson LE, Lawrence LM, Pool B, Van Der Kroef M, Ashimbayeva E, Britto D, Harper JL, Lieschke GJ, Astin JW, Crosier KE, Dalbeth N, Crosier PS
Journal of Clinical Investigation - vol. 128 1752-1771 (2018)

Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging […]

Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development

Antimicrob. Agents Chemother

Gina Wall AKC
Antimicrob. Agents Chemother (2018)

Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosoph ila cardiac model of Friedreich ’ s Keywords : Summary statement : Abstract :

Dis Model Mech.

Palandri A, Martin E, Russi M, Rera M
Dis Model Mech. - vol. 11 1-22 (2018)

SynAggreg : A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds

J Mol Biol

Aviolat H, Nominé Y, Gioria S, Bonhoure A
J Mol Biol - vol. 430 5257-5279 (2018)

Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

Disease Models & Mechanisms

Chakraborty M, Sellier C, Ney M, Pascal V, Charlet-berguerand N
Disease Models & Mechanisms - vol. 1 1-12 (2018)

A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry

SLAS Discovery

Tione Buranda CG
SLAS Discovery 1 (2018)

Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter a-b

Cell Mol Gastroenterol Hepatol

Sandra M. W. van de Wiel DRDW
Cell Mol Gastroenterol Hepatol - vol. 5 223-237 (2018)

Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens


Mamouei Z, Alqarihi A, Singh S, Xu S, Mansour MK, Ibrahim AS
mspher - vol. 3 1-11 (2018)

Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice

Diabetes Obes Metab.

Jung H, Park S, Hee S, Lee D, Lee I, Kim M, Jeong Y, Hee Y, Bs L
Diabetes Obes Metab. 1-14 (2018)

Antimicrobial and Antibiofilm Activity of Synergistic Combinations of a Commercially Available Small Compound Library With Colistin Against Pseudomonas aeruginosa

Frontiers in Micro

Torres NS, Montelongo-jauregui D, Abercrombie JJ, Srinivasan A, Lopez-ribot JL, Ramasubramanian AK
Frontiers in Micro - vol. 9 1-12 (2018)