Latest Publications Alexidine Dihydrochloride Has Broad-Spectrum Activities
Mamouei, Z. et al.
mSphere 1–11 (2018)
Invasive fungal infections due to Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans constitute a substantial threat to hospitalized immunocompromised patients. Further, the presence of drug-recalcitrant biofilms on medical devices and emergence of drug-resistant fungi, such as Candida auris, introduce treatment challenges with current antifungal drugs. Worse, currently there is no approved drug capable of obviating preformed biofilms, which increase the […]
Latest Publications Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy.
Chakraborty, M., Sellier, C., Ney, M., Pascal, V. & Charlet-berguerand, N.
Disease models & mechanisms 1–12 (2005)
Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of […]
Latest Publications Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosoph ila cardiac model of Friedreich ’ s Keywords : Summary statement :
Palandri, A., Martin, E., Russi, M. & Rera, M.
Disease Models & Mechanisms (2018)
Friedreich’s ataxia (FA) is caused by reduced levels of frataxin, a highly conserved mitochondrial protein. There is currently no effective treatment for this disease, which is characterized by progressive neurodegeneration and cardiomyopathy, the latter being the most common cause of death in patients. We previously developed a Drosophila melanogaster cardiac model of FA, in which the fly […]