Antimicrobial and Antibiofilm Activity of Synergistic Combinations of a Commercially Available Small Compound Library With Colistin Against Pseudomonas aeruginosa

Frontiers in Micro

Torres NS, Montelongo-jauregui D, Abercrombie JJ, Srinivasan A, Lopez-ribot JL, Ramasubramanian AK
Frontiers in Micro - vol. 9 1-12 (2018)

Extensive impact of non-antibiotic drugs on human gut bacteria


Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H, Patil KR, Bork P, Typas A
Nature - vol. 555 623-628 (2018)

A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Here, we screened more than 1,000 marketed drugs against 40 representative gut bacterial strains, and found that 24% of the drugs with human targets, including members of all therapeutic classes, inhibited […]

Screening for biologically annotated drugs that trigger triacylglycerol accumulation in the diatom Phaeodactylum

Plant Physiology

Melissa Conte JL
Plant Physiology 532-552 (2018)

Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions

Bioorganic and Medicinal Chemistry Letters

Ren J, Dsouza NR, Deng H, Lee H, Bouvier M, Johnson ME
Bioorganic and Medicinal Chemistry Letters - vol. 28 2837-2841 (2018)

The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an important role in Ad infections, which is the causative agent of a series of gastrointestinal, respiratory and ocular diseases. The objective of this research is to evaluate the essential interactions between E3-19K and HLA-A2 using the X-ray crystal structure […]

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

Varbanov HP, Kuttler F, Banfi D, Turcatti G, Dyson J

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA E ffl ux Pump Inhibitors

J. Med. Chem.

Astolfi A, Felicetti T, Iraci N, Manfroni G, Massari S, Pietrella D, Tabarrini O, Kaatz GW, Barreca ML, Sabatini S, Cecchetti V
J. Med. Chem. - vol. 60 1598-1604 (2017)

Toward the identi fi cation of viral cap-methyltransferase inhibitors by fl uorescence screening assay

Antiviral Research

Aouadi W, C E, Coutard B, Martin B, Aouadi W, Debart F, Jacques J, Marie J, Morice C, Jung M, Canard B, Guillemot J, Decroly E
Antiviral Research - vol. 144 330-339 (2017)

Applications of chemogenomic library screening in drug discovery

Nature Publishing Group

Jones LH, Bunnage ME
Nature Publishing Group - vol. 16 285-296 (2017)

Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins

ACS Chem. Biol.

Jones CL, Njomen E, Dexheimer TS, Tepe JJ
ACS Chem. Biol. - vol. 12 2240−2247 (2017)

High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors Report High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdo

C Chauvin AL, Delattre O, Nery ED, Leruste A, Tauziede-espariat A, Andrianteranagna M, Surdez D