Young SM
Journal of Biomolecular Screening - vol. 10 374-382 (2005)
Mizumoto N, Gao J, Matsushima H, Ogawa Y, Tanaka H, Takashima A
Blood - vol. 106 3082-3090 (2005)
Bakshi P, Liao Y, Gao J, Ni J, Stein R, Yeh L, Wolfe MS
Journal of Biomolecular Screening - vol. 10 1-12 (2005)
Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI
Molecular pharmacology - vol. 68 1301-1310 (2005)
Ruebel S, Stuemke M
- vol. 1 11 (2004)
The invention relates to a bath for the electrodeposition of gold and gold alloys and to its use for producing dental moldings. In this bath, the gold is in the form of a gold sul?te complex. The bath according to the invention and/or the use according to the invention is distinguished by the fact that […]
Wermuth CG
Journal of Medicinal Chemistry - vol. 47 1303-1314 (2004)
Edwards BS, Oprea T, Prossnitz ER, Sklar LA
Current Opinion in Chemical Biology - vol. 8 392-398 (2004)
Flow cytometry is a mature platform for quantitative multi-parameter measurement of cell fluorescence. Recent innovations allow up to 30-fold faster serial processing of bulk cell samples. Homogeneous discrimination of free and cell-bound fluorescent probe eliminates wash steps to streamline sample processing. Compound screening throughput may be further enhanced by multiplexing of assays on color-coded bead […]
Gaud A, Simon JM, Witzel T, Carre-Pierrat M, Wermuth CG, Ségalat L
Neuromuscular Disorders - vol. 14 365-370 (2004)
Duchenne muscular dystrophy is a degenerative muscular disease caused by mutations in the dystrophin gene. There is no curative treatment against Duchenne muscular dystrophy. In several countries, the steroid prednisone (or analogs) is prescribed as a palliative treatment. In the model animal Caenorhabditis elegans, mutations of the dys-1 dystrophin-like gene lead to a muscular degenerative […]
Ahn JS
Journal of Biomolecular Screening - vol. 9 122-131 (2004)
Doan T
Drug Discovery Today: TARGETS - vol. 3 191-197 (2004)
Modern drug discovery includes a progression from the identification of molecular targets pertinent to disease processes to the validation of those targets and compound screening to modulate the targets of interest.To save time and reduce cost,analysis of gene function can be rapidly assessed in model organisms using several approaches, including mutagenesis, antisense knockdown and chemical […]
