Discovery of novel immunostimulants by dendritic-cell – based functional screening


Mizumoto N, Gao J, Matsushima H, Ogawa Y, Tanaka H, Takashima A
Blood - vol. 106 3082-3090 (2005)

A High-Throughput Screen to Identify Inhibitors of Amyloid beta-Protein Precursor Processing

Journal of Biomolecular Screening

Bakshi P, Liao Y, Gao J, Ni J, Stein R, Yeh L, Wolfe MS
Journal of Biomolecular Screening - vol. 10 1-12 (2005)

Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide

Molecular pharmacology

Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI
Molecular pharmacology - vol. 68 1301-1310 (2005)

Receptor Binding Techniques

Nethods in Molecular Biology

Tobergte DR, Curtis S
Nethods in Molecular Biology - vol. Second Edi 17-25 (2005)

applicability for this approach.

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.

Proceedings of the National Academy of Sciences of the United States of America

Ray SS, Nowak RJ, Brown RH, Lansbury PT
Proceedings of the National Academy of Sciences of the United States of America - vol. 102 3639-3644 (2005)

Familial amyotrophic lateral sclerosis (FALS) is a fatal motor neuron disease that is caused by mutations in the gene encoding superoxide dismutase-type 1 (SOD1). The affected regions of the FALS brain are characterized by aggregated SOD1, and the mutations that destabilize SOD1 appear to promote its aggregation in vitro. Because dissociation of the native SOD1 […]

Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

Nat Rev Drug Discov

O'Connor KA, Roth BL
Nat Rev Drug Discov - vol. 4 1005-1014 (2005)

With the annotation of the human genome approaching completion, public-sector researchers – spurred in part by various National Institutes of Health Roadmap Initiatives – have become increasingly engaged in drug discovery and development efforts. Although large and diverse chemical libraries of ‘drug-like’ compounds can be readily screened to yield chemically novel scaffolds, transforming these ‘chemical […]

( 19 ) United States ( 12 ) Patent Application Publication ( 10 ) Pub . No .: US 2010 / 0041620 A1 Publication Classi ? cation 6 Weak Followup Patent Application Publication

Ruebel S, Stuemke M
- vol. 1 11 (2004)

The invention relates to a bath for the electrodeposition of gold and gold alloys and to its use for producing dental moldings. In this bath, the gold is in the form of a gold sul?te complex. The bath according to the invention and/or the use according to the invention is distinguished by the fact that […]

Selective Optimization of Side Activities: Another Way for Drug Discovery

Journal of Medicinal Chemistry

Wermuth CG
Journal of Medicinal Chemistry - vol. 47 1303-1314 (2004)

Flow cytometry for high-throughput, high-content screening

Current Opinion in Chemical Biology

Edwards BS, Oprea T, Prossnitz ER, Sklar LA
Current Opinion in Chemical Biology - vol. 8 392-398 (2004)

Flow cytometry is a mature platform for quantitative multi-parameter measurement of cell fluorescence. Recent innovations allow up to 30-fold faster serial processing of bulk cell samples. Homogeneous discrimination of free and cell-bound fluorescent probe eliminates wash steps to streamline sample processing. Compound screening throughput may be further enhanced by multiplexing of assays on color-coded bead […]

Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans

Neuromuscular Disorders

Gaud A, Simon JM, Witzel T, Carre-Pierrat M, Wermuth CG, Ségalat L
Neuromuscular Disorders - vol. 14 365-370 (2004)

Duchenne muscular dystrophy is a degenerative muscular disease caused by mutations in the dystrophin gene. There is no curative treatment against Duchenne muscular dystrophy. In several countries, the steroid prednisone (or analogs) is prescribed as a palliative treatment. In the model animal Caenorhabditis elegans, mutations of the dys-1 dystrophin-like gene lead to a muscular degenerative […]