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Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells

Free Radical Biology and Medicine

Timiri Shanmugam PS, Nair RP, De Benedetti A, Caldito G, Abreo F, Sunavala-Dossabhoy G
Free Radical Biology and Medicine - vol. 93 217-226 (2016)

Accidental or medical radiation exposure of the salivary glands can gravely impact oral health. Previous studies have shown the importance of Tousled-like kinase 1 (TLK1) and its alternate start variant TLK1B in cell survival against genotoxic stresses. Through a high-throughput library screening of natural compounds, the phenolic phytochemical, gallic acid (GA), was identified as a […]

Publications
Identification of novel molecules targeting cartilage aging as osteoarthritis therapeutics

Osteoarthritis and Cartilage

Nogueira U, Dominguez E, Loza M, Blanco F, Carames B
Osteoarthritis and Cartilage - vol. 24 S18-S19 (2016)

Publications
In Memoriam: Professor Camille-Georges Wermuth

European Journal of Medicinal Chemistry

Sapi J
European Journal of Medicinal Chemistry - vol. 108 741 (2016)

Publications
Multi-omics “Upstream Analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer

EUPROT

Koschmann J, Poroikov V, Wingender KE
EUPROT (2016)

Publications
Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer’s disease

Alzheimer's and Dementia: Translational Research and Clinical Interventions

Koppel J, Jimenez H, Adrien L, Greenwald B, Marambaud P, Cinamon E, Davies P
Alzheimer's and Dementia: Translational Research and Clinical Interventions - vol. 2 121-130 (2016)

? 2016 The AuthorsIntroduction The use of antipsychotic medications in Alzheimer’s disease has been associated with an increased risk of mortality in clinical trials. However, an older postmortem literature suggests that those with schizophrenia treated in an era of exclusively conventional antipsychotic medications had a surprisingly low incidence of tau pathology. No previously published studies […]

Publications
Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples

Analytical and Bioanalytical Chemistry

Guetschow ED, Kumar S, Lombard DB, Kennedy RT
Analytical and Bioanalytical Chemistry - vol. 408 721-731 (2016)

Publications
Treatment of chronic enterovirus encephalitis with fluoxetine in a patient with X-linked agammaglobulinemia

Pediatric Neurology

Gofshteyn J, Cárdenas AM, Bearden D
Pediatric Neurology (2016)

Publications
RE(ACT) Congress. 9-12 March 2016, Barcelona. 3rd International Congress on Research of Rare and Orphan Diseases. 9th to 12th March 2016. Crowne Plaza Barcelona – Fira Center, Barcelona, Spain: Abstracts

Molecular Syndromology

Foundation S, Orphan ON, Suisse F, La P, Sur R, Maladies LES, Svizzera F, La PER, Sulle R, Orfane M
Molecular Syndromology - vol. 6 304-335 (2016)

Publications
High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

Disease Models & Mechanisms

Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJV, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R
Disease Models & Mechanisms - vol. 9 685-696 (2016)

Publications
Fragment pharmacophore-based in silico screening: A powerful approach for efficient lead discovery

Med. Chem. Commun.

Deyon-Jung L, Morice C, Chéry F, Gay J, Langer T, Frantz M, Rozot R, Dalko-Csibe M
Med. Chem. Commun. - vol. 7 506-511 (2016)