Success Stories

Virtual screening in lead discovery: A viewpoint


Oprea TI
Molecules - vol. 7 51-62 (2002)

Virtual screening (VS) methods have emerged as an adaptive response to massive throughput synthesis and screening technologies. Based on the structure-permeability paradigm, the Lipinski rule of five has become a standard property filtering protocol for VS. Three possible VS scenarios with respect to optimising binding affinity and pharmacokinetic properties are discussed. The parsimony principle for […]

Development of an Assay to Screen for Inhibitors of Tau Phosphorylation by Cdk5

Journal of Biomolecular Screening

Ahn JS
Journal of Biomolecular Screening - vol. 9 122-131 (2004)

High-throughput target validation in model organisms

Drug Discovery Today: TARGETS

Doan T
Drug Discovery Today: TARGETS - vol. 3 191-197 (2004)

Modern drug discovery includes a progression from the identification of molecular targets pertinent to disease processes to the validation of those targets and compound screening to modulate the targets of interest.To save time and reduce cost,analysis of gene function can be rapidly assessed in model organisms using several approaches, including mutagenesis, antisense knockdown and chemical […]

Multi-parameter high throughput screening assays (MPHTS)


Altar CA, Brockman JA, Evans D, Hook DJ, Klimczak LJ, Laeng P, Palfreyman M, Rajan P
Society - vol. 9 51 (2005)

The present invention relates to screening methods and assays that are referred to herein as multi-parameter hight throughput screening (MPHTS) assays. These MPHTS assays are useful for identifying candidate pharmaceutical compounds. In particular, the screening methods of this invention may be used to identify compounds that have potential therapeutic bene?ts for the treatment of neurop […]

High-Throughput Screening with HyperCyt(R) Flow Cytometry to Detect Small Molecule Formylpeptide Receptor Ligands

Journal of Biomolecular Screening

Young SM
Journal of Biomolecular Screening - vol. 10 374-382 (2005)

Discovery of novel immunostimulants by dendritic-cell – based functional screening


Mizumoto N, Gao J, Matsushima H, Ogawa Y, Tanaka H, Takashima A
Blood - vol. 106 3082-3090 (2005)

A High-Throughput Screen to Identify Inhibitors of Amyloid beta-Protein Precursor Processing

Journal of Biomolecular Screening

Bakshi P, Liao Y, Gao J, Ni J, Stein R, Yeh L, Wolfe MS
Journal of Biomolecular Screening - vol. 10 1-12 (2005)

Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide

Molecular pharmacology

Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI
Molecular pharmacology - vol. 68 1301-1310 (2005)

Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its Application in Screening of a 100,000-Compound Library

Journal of Biomolecular Screening

Severson WE, Shindo N, Sosa M, Fletcher T, White EL, Ananthan S, Jonsson CB
Journal of Biomolecular Screening - vol. 12 33-40 (2006)


Journal of Physiology-Paris

Shimahara T
Journal of Physiology-Paris - vol. 99 73-74 (2006)