Success Stories

Publications (2018-2020) Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosoph ila cardiac model of Friedreich ’ s Keywords : Summary statement :

Palandri, A., Martin, E., Russi, M. & Rera, M.
Disease Models & Mechanisms (2018)

Friedreich’s ataxia (FA) is caused by reduced levels of frataxin, a highly conserved mitochondrial protein. There is currently no effective treatment for this disease, which is characterized by progressive neurodegeneration and cardiomyopathy, the latter being the most common cause of death in patients. We previously developed a Drosophila melanogaster cardiac model of FA, in which the fly […]

Publications (2018-2020) Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy.

Chakraborty, M., Sellier, C., Ney, M., Pascal, V. & Charlet-berguerand, N.
Disease models & mechanisms 1–12 (2005)

Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of […]

Publications (2018-2020) Alexidine Dihydrochloride Has Broad-Spectrum Activities

Mamouei, Z. et al.
mSphere 1–11 (2018)

Invasive fungal infections due to Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans constitute a substantial threat to hospitalized immunocompromised patients. Further, the presence of drug-recalcitrant biofilms on medical devices and emergence of drug-resistant fungi, such as Candida auris, introduce treatment challenges with current antifungal drugs. Worse, currently there is no approved drug capable of obviating preformed biofilms, which increase the […]

Publications (2018-2020) Antimicrobial and Antibiofilm Activity of Synergistic Combinations of a Commercially Available Small Compound Library With Colistin Against Pseudomonas aeruginosa.

Torres, N. S. et al.
Front. Microbiol. 1–12 (2018)

Biofilm-associated Pseudomonas aeruginosa infections remain a significant clinical challenge since the conventional antibiotic treatment or combination therapies are largely ineffective; and new approaches are needed. To circumvent the major challenges associated with discovery of new antimicrobials, we have screened a library of compounds that are commercially available and approved by the FDA (Prestwick Chemical Library) against P. aeruginosa for […]

Publications (2018-2020) Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice.

Jung, H. et al.
Diabetes Obes Metab. 1–14 (2018)

Aims Although peroxisome proliferator‐activated receptors (PPARs)α/γ dual agonists can be beneficial for treatment of dyslipidemia in patients with type 2 diabetes, their use is limited owing to various side effects, including body weight gain, edema, and heart failure. We aimed to demonstrate that amodiaquine, an antimalarial agent, has potential as a PPARα/γ dual agonist with […]

Publications (2018-2020) Screening for Biologically Annotated Drugs That Trigger Triacylglycerol Accumulation in the Diatom Phaeodactylum

Melissa Conte, Josselin Lupette, Khawla Seddiki, Coline Meï, Lina-Juana Dolch, Valérie Gros, Caroline Barette, Fabrice Rébeillé, Juliette Jouhet, E. M.
Plant Physiol. (2018)

Microalgae are a promising feedstock for the production of triacylglycerol (TAG) for a variety of potential applications, ranging from food and human health to biofuels and green chemistry. However, obtaining high TAG yields is challenging. A phenotypic assay for the accumulation of oil droplets was developed to screen a library of 1,200 drugs, annotated with […]

Publications (2018-2020) Development of a semi-automated image-based high-throughput drug screening system

Eren, R. O. et al.
Front Biosci 10 242–253 (2018)

We previously reported that the innate sensing of the endosymbiont Leishmania RNA virus 1 (LRV1) within Leishmania (Viannia) guyanensis through Toll-like receptor 3, worsens the pathogenesis of parasite infection in mice. The presence of LRV1 has been associated with the failure of first-line treatment in patients infected with LRV1 containing –L. guyanensis and –L. braziliensis parasites. Here, we established a semi-automated […]

Publications (2018-2020) Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter a-b.

Sandra M. W. van de Wiel, D. Rudi de Waart, Ronald P. J. Oude Elferink, and S. F. J. van de G.
Cell Mol Gastroenterol Hepatol 5 223–237 (2018)

Background & Aims The organic solute transporter α-β (OSTα-OSTβ) mainly facilitates transport of bile acids across the basolateral membrane of ileal enterocytes. Therefore, inhibition of OSTα-OSTβ might have similar beneficial metabolic effects as intestine-specific agonists of the major nuclear receptor for bile acids, the farnesoid X receptor (FXR). However, no OSTα-OSTβ inhibitors have yet been […]

Publications (2018-2020) A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry.

Tione Buranda, Catherine Gineste, Yang Wu, Virginie Bondu, Dominique Perez, Kaylin R. Lake, Bruce S. Edwards, L. A. S.
SLAS Discov. 1 (2018)

Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which infects more than 200,000 people worldwide. Sin Nombre virus (SNV) and Andes virus (ANDV) cause the most severe form of HCPS, with case fatality ratios of 30%-40%. There are no specific therapies or vaccines for SNV. Using high-throughput flow cytometry, we […]

Publications (2018-2020) SynAggreg : A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds

Aviolat, H., Nominé, Y., Gioria, S. & Bonhoure, A.
Journal of Molecular Biology 430 1–23 (2018)

Numerous proteins can coalesce into amyloid self-assemblies, which are responsible for a class of diseases called amyloidoses, but which can also fulfill important biological functions and are of great interest for biotechnology. Amyloid aggregation is a complex multi-step process, poorly prone to detailed structural studies. Therefore, small molecules interacting with amyloids are often used as tools to probe […]