Success Stories


Journal of Physiology-Paris

Shimahara T
Journal of Physiology-Paris - vol. 99 73-74 (2006)

Integration of virtual and physical screening

Drug Discovery Today: Technologies

Fara DC, Oprea TI, Prossnitz ER, Bologa CG, Edwards BS, Sklar LA
Drug Discovery Today: Technologies - vol. 3 377-385 (2006)

High-throughput screening (HTS) represents the dominant technique for the identification of new lead compounds in current drug discovery. It consists of physical screening (PS) of large libraries of chemicals against one or more specific biological targets. Virtual screening (VS) is a strategy for in silico evaluation of chemical libraries for a given target, and can […]

A High-Throughput Drug Screen Targeted to the 5’Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA

Journal of Biomolecular Screening

Bandyopadhyay S
Journal of Biomolecular Screening - vol. 11 469-480 (2006)

A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential

Tsetsarkin KA, Vanlandingham DL, Mcgee CE, Higgs S
- vol. 3 (2007)

Infection with chikungunya virus in Italy: an outbreak in a temperate region

The Lancet

Rezza G, Nicoletti L, Angelini R, Romi R, Finarelli A, Panning M, Cordioli P, Fortuna C, Boros S, Magurano F, Silvi G, Angelini P, Dottori M, Ciufolini M, Majori G, Cassone A
The Lancet - vol. 370 1840-1846 (2007)

BACKGROUND Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy. METHODS After reports of a large number of cases of febrile illness of unknown origin in two contiguous villages in northeastern […]

A Novel Inhibitor of Mycobacterium tuberculosis

Journal of Biomolecular Screening

White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM
Journal of Biomolecular Screening 100-105 (2007)

Drug Repurposing

MSI Consultancy

Stuart-Kregor P
MSI Consultancy (2007)

Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases

Journal of Biomolecular Screening

Ivey FD, Wang L, Demirbas D, Allain C, Hoffman CS
Journal of Biomolecular Screening - vol. 13 62-71 (2007)

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

Biochemical and Biophysical Research Communications

Crowe A, Ballatore C, Hyde E, Trojanowski JQ, Lee VM
Biochemical and Biophysical Research Communications - vol. 358 1-6 (2007)

A library of ∼51,000 compounds was interrogated by high throughput screening (HTS) using a heparin-induced tau fibrillization assay. HTS was conducted with bacterially expressed recombinant tau fragment K18 and the reaction was monitored by thioflavine T fluorescence. Hits meeting criteria set for selection in HTS were further evaluated in a panel of assays designed (a) […]

High-Troughput Identification of Inhibitors of Human Mitochondrial Peptide Deformylase

J. Biomol. Screen

Antczak C, Shum D, Escobar S, Bassit B, Seshan VE, Wu N, Yang G, Li Y, Scheinberg DA, Djaballah H
J. Biomol. Screen - vol. 12 521-535 (2007)