A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

Proceedings of the National Academy of Sciences
Il y a 18 années

10.1073/pnas.0801661105 Alternative splicing has emerged as a promising therapeutic target in a number of human disorders. However, the discovery of compounds that target the splicing reaction has been hindered by the lack of suitable high-throughput screening assays. Conversely, the effects of known drugs on the splicing reaction are mostly unclear and not routinely assessed. We […]

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