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Publications
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine ␤ -synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon

Pharmacological Research

Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-garcía I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C
Pharmacological Research - vol. 113 18-37 (2016)

Publications
Characterization and application of two RANK-specific antibodies with different biological activities

Immunology Letters

Chypre M, Seaman J, Cordeiro OG, Willen L, Knoop KA, Buchanan A, Sainson RCA, Williams IR, Yagita H, Schneider P, Mueller CG
Immunology Letters - vol. 171 5-14 (2016)

Antibodies play an important role in therapy and investigative biomedical research. The TNF-family member Receptor Activator of NF-??B (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. However, the study of RANK biology has been hampered by missing or insufficient […]

Publications
Identifying ligands at orphan GPCRs : current status using structure-based approaches Tables of Links

British Journal of Pharmacology

Ngo T, Kufareva I, Coleman JLJ, Graham RM, Abagyan R, Smith NJ
British Journal of Pharmacology - vol. 173 2934-2951 (2016)

Publications
Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury

Journal of Neurotrauma.

Sylvie Liabeuf LS
Journal of Neurotrauma. - vol. 34 3397-3406 (2017)

Publications
New use of an old drug: Inhibition of breast cancer stem cells by benztropine mesylate

Oncotarget

Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M
Oncotarget - vol. 8 1007-1022 (2017)

Cancer stem cells (CSCs) play major roles in cancer initiation, metastasis, recurrence and therapeutic resistance. Targeting CSCs represents a promising strategy for cancer treatment. The purpose of this study was to identify selective inhibitors of breast CSCs (BCSCs). We carried out a cell-based phenotypic screening with cell viability as a primary endpoint, using a collection […]

Publications
Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells . Implication of inositol 1 , 4 , 5-triphosphate receptor dependent

Biochimica et Biophysica Acta

Dong J, Aulestia FJ, Assad S, Zeniou M, Gustavo L, El-habr EA, Daubeuf F, Tounsi N, Cheshier SH, Frossard N, Junier M, Chneiweiss H, Néant I, Moreau M, Leclerc C, Haiech J, Kilhoffer M
Biochimica et Biophysica Acta - vol. 1864 1018-1027 (2017)

Publications
High-Throughput Screen Fails to Identify Compounds That Enhance Residual Enzyme Activity of Mutant N- Acetyl- a -Glucosaminidase in Mucopolysaccharidosis Type

JIMD Reports

O. L. M. Meijer PVDB
JIMD Reports (2017)

Publications
Repositioning approved drugs for the treatment of problematic cancers using a screening approach

Varbanov HP, Kuttler F, Banfi D, Turcatti G, Dyson J
(2017)

Publications
Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA E ffl ux Pump Inhibitors

J. Med. Chem.

Astolfi A, Felicetti T, Iraci N, Manfroni G, Massari S, Pietrella D, Tabarrini O, Kaatz GW, Barreca ML, Sabatini S, Cecchetti V
J. Med. Chem. - vol. 60 1598-1604 (2017)

Publications
Toward the identi fi cation of viral cap-methyltransferase inhibitors by fl uorescence screening assay

Antiviral Research

Aouadi W, C E, Coutard B, Martin B, Aouadi W, Debart F, Jacques J, Marie J, Morice C, Jung M, Canard B, Guillemot J, Decroly E
Antiviral Research - vol. 144 330-339 (2017)