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Publications
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

Biochemical and Biophysical Research Communications

Crowe A, Ballatore C, Hyde E, Trojanowski JQ, Lee VM
Biochemical and Biophysical Research Communications - vol. 358 1-6 (2007)

A library of ∼51,000 compounds was interrogated by high throughput screening (HTS) using a heparin-induced tau fibrillization assay. HTS was conducted with bacterially expressed recombinant tau fragment K18 and the reaction was monitored by thioflavine T fluorescence. Hits meeting criteria set for selection in HTS were further evaluated in a panel of assays designed (a) […]

Publications
High-Troughput Identification of Inhibitors of Human Mitochondrial Peptide Deformylase

J. Biomol. Screen

Antczak C, Shum D, Escobar S, Bassit B, Seshan VE, Wu N, Yang G, Li Y, Scheinberg DA, Djaballah H
J. Biomol. Screen - vol. 12 521-535 (2007)

Publications
Identification of Small Molecule Inhibitors of β–Amyloid Cytotoxicity through a Cell-based High-Throughput Screening Platform

Journal of Biomolecular Screening

Seyb KI, Schuman ER, Ni J, Huang M, Michaelis ML, Glicksman MA
Journal of Biomolecular Screening - vol. 13 870-878 (2008)

Publications
Molecule Inhibitors of the Mitotic Kinase Haspin By High-Throughput Screening Using a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer Assay

Journal of biomolecular screening

Patnaik D, Xian J
Journal of biomolecular screening - vol. 13 1025-1034 (2008)

Publications
A High-Throughput Screening Assay for Small Molecules

Krysan DJ, Didone L
(2008)

Publications
Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs

PLoS ONE

D T, Reis SD, Gug F, Huang C, Sabate R, Kikovska E, Talarek N, Vilette D
PLoS ONE - vol. 3 (2008)

Publications
Incidence and specificity of drug-induced trafficking inhibition of cardiac ion channels

Journal of Pharmacological and Toxicological Methods

Wible BA
Journal of Pharmacological and Toxicological Methods - vol. 60 223 (2009)

Publications
Computer-aided prediction of rodent carcinogenicity by PASS and CISOC-PSCT

QSAR and Combinatorial Science

Lagunin A, Filimonov D, Zakharov A, Xie W, Huang Y, Zhu F, Shen T, Yao J, Poroikov V
QSAR and Combinatorial Science - vol. 28 806-810 (2009)

Computer-aided prediction of rodent carcinogenicity for the external test set consisting of 293 chemicals was performed by PASS (Prediction of Activity Spectra for Substances) and by CISOC-PSCT. The set included 64 carcinogens from ISS Carcinogens Data Bank and 229 noncarcinogens from the Prestwick Chemical Library. We calculated the accuracy of carcinogenicity prediction by PASS and […]

Publications
A High-Throughput Method to Identify Novel Senescene-Inducing Compounds

J Biomol Screen

Ewald JA, Peters N, Desotelle JA, Hoffmann FM, Jarrard DF
J Biomol Screen - vol. 14 853-858 (2009)

Publications
NIH Public Access

Manuscript A, Formation HTF
- vol. 358 1-6 (2009)