Success Stories

Identifying ligands at orphan GPCRs : current status using structure-based approaches Tables of Links

British Journal of Pharmacology

Ngo T, Kufareva I, Coleman JLJ, Graham RM, Abagyan R, Smith NJ
British Journal of Pharmacology - vol. 173 2934-2951 (2016)

Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury

Journal of Neurotrauma.

Sylvie Liabeuf LS
Journal of Neurotrauma. - vol. 34 3397-3406 (2017)

New use of an old drug: Inhibition of breast cancer stem cells by benztropine mesylate


Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M
Oncotarget - vol. 8 1007-1022 (2017)

Cancer stem cells (CSCs) play major roles in cancer initiation, metastasis, recurrence and therapeutic resistance. Targeting CSCs represents a promising strategy for cancer treatment. The purpose of this study was to identify selective inhibitors of breast CSCs (BCSCs). We carried out a cell-based phenotypic screening with cell viability as a primary endpoint, using a collection […]

Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells . Implication of inositol 1 , 4 , 5-triphosphate receptor dependent

Biochimica et Biophysica Acta

Dong J, Aulestia FJ, Assad S, Zeniou M, Gustavo L, El-habr EA, Daubeuf F, Tounsi N, Cheshier SH, Frossard N, Junier M, Chneiweiss H, Néant I, Moreau M, Leclerc C, Haiech J, Kilhoffer M
Biochimica et Biophysica Acta - vol. 1864 1018-1027 (2017)

High-Throughput Screen Fails to Identify Compounds That Enhance Residual Enzyme Activity of Mutant N- Acetyl- a -Glucosaminidase in Mucopolysaccharidosis Type

JIMD Reports

O. L. M. Meijer PVDB
JIMD Reports (2017)

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

Varbanov HP, Kuttler F, Banfi D, Turcatti G, Dyson J

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA E ffl ux Pump Inhibitors

J. Med. Chem.

Astolfi A, Felicetti T, Iraci N, Manfroni G, Massari S, Pietrella D, Tabarrini O, Kaatz GW, Barreca ML, Sabatini S, Cecchetti V
J. Med. Chem. - vol. 60 1598-1604 (2017)

Toward the identi fi cation of viral cap-methyltransferase inhibitors by fl uorescence screening assay

Antiviral Research

Aouadi W, C E, Coutard B, Martin B, Aouadi W, Debart F, Jacques J, Marie J, Morice C, Jung M, Canard B, Guillemot J, Decroly E
Antiviral Research - vol. 144 330-339 (2017)

Applications of chemogenomic library screening in drug discovery

Nature Publishing Group

Jones LH, Bunnage ME
Nature Publishing Group - vol. 16 285-296 (2017)

Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins

ACS Chem. Biol.

Jones CL, Njomen E, Dexheimer TS, Tepe JJ
ACS Chem. Biol. - vol. 12 2240−2247 (2017)