Publications


Publications
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

Proceedings of the National Academy of Sciences

Stoilov P, Lin C, Damoiseaux R, Nikolic J, Black DL
Proceedings of the National Academy of Sciences - vol. 105 11218-11223 (2008)

10.1073/pnas.0801661105 Alternative splicing has emerged as a promising therapeutic target in a number of human disorders. However, the discovery of compounds that target the splicing reaction has been hindered by the lack of suitable high-throughput screening assays. Conversely, the effects of known drugs on the splicing reaction are mostly unclear and not routinely assessed. We […]

Publications
A High-Throughput Screening Assay for Small Molecules

Krysan DJ, Didone L
(2008)

Publications
Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization.

Journal of biomolecular screening

Nakamura K, Zawistowski JS, Hughes MA, Sexton JZ, Yeh L, Johnson GL, Scott JE
Journal of biomolecular screening - vol. 13 396-405 (2008)

Twenty human proteins encode Phox/Bem1p (PB1) domains, which are involved in forming protein heterodimers. MEKK2, MEKK3, and MEK5 are 3 serine-threonine protein kinases that have PB1 domains. MEKK2, MEKK3, and MEK5 are the MAP3Ks and the MAP2K in the ERK5 mitogen-activated protein kinase (MAPK) signaling module. ERK5 is a critical MAPK for both development of […]

Publications
Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs

PLoS ONE

D T, Reis SD, Gug F, Huang C, Sabate R, Kikovska E, Talarek N, Vilette D
PLoS ONE - vol. 3 (2008)

Publications
Assay for therapies that inhibit expression of the cytosolic CU/ZN superoxide dismutase (SOD1) gene

Brown RH, Broom W
- vol. 1 (2008)

Publications
A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential

Tsetsarkin KA, Vanlandingham DL, Mcgee CE, Higgs S
- vol. 3 (2007)

Publications
Infection with chikungunya virus in Italy: an outbreak in a temperate region

The Lancet

Rezza G, Nicoletti L, Angelini R, Romi R, Finarelli A, Panning M, Cordioli P, Fortuna C, Boros S, Magurano F, Silvi G, Angelini P, Dottori M, Ciufolini M, Majori G, Cassone A
The Lancet - vol. 370 1840-1846 (2007)

BACKGROUND Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy. METHODS After reports of a large number of cases of febrile illness of unknown origin in two contiguous villages in northeastern […]

Publications
A Novel Inhibitor of Mycobacterium tuberculosis

Journal of Biomolecular Screening

White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM
Journal of Biomolecular Screening 100-105 (2007)

Publications
Drug Repurposing

MSI Consultancy

Stuart-Kregor P
MSI Consultancy (2007)

Publications
Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases

Journal of Biomolecular Screening

Ivey FD, Wang L, Demirbas D, Allain C, Hoffman CS
Journal of Biomolecular Screening - vol. 13 62-71 (2007)